Airway Smooth Muscles Relaxant and Mast Cells Stabilizing Activity of Some Medicinal Plants Used in Managing Asthma in North-Western Nigeria

Ibrahim M. Aliyu1*, Mohammed G. Magaji1, Jamilu Yau1, Danjuma N. Muhammed1, Zakiyyah Y.Y. Ibrahim2
1Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria – Nigeria
2Department of Pharmacognosy and Ethnomedicine, Usmanu Danfodiyo University, Sokoto – Nigeria



Corresponding Author: [email protected]; Tel: +234-80-72360276
Recieved Date: 12 January 2022; Accepted Date: 15 August 2022; Published Date: 03 September
Citation: Aliyu IM, Magaji MG, Yau J, Muhammed DN, Ibrahim ZYY. Airway Smooth Muscles Relaxant and Mast Cells Stabilizing Activity of Some Medicinal Plants Used in Managing Asthma in North-Western Nigeria. Trop J Nat Prod Res. 2022; 6(8):1241-1248. http://www.doi.org/10.26538/tjnpr/v6i8.14
Copyright:
© 2022 Aliyu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at  Tropical Journal of Natural Product Research











ABSTRACT

Cassia occidentalis whole plant (C.O.W.P), Jatropha curcas leaves (J.C.L.), Ximenia americana Santalales leaves (X.A.L.), and Eucalyptus citriodora leaves (E.C.L.) have been revealed to be widely used by locals of north-western Nigeria for the management of asthma. This study was aimed at providing a pharmacological rationale for the ethnomedical use of these plants in the management of asthma.
The four extracts were screened for their effects on the spontaneous contraction of isolated rabbit ileum strip; also on pre-contracted isolated guinea Pig ileum strip; on pre-contracted isolated Guinea Pig trachea chain; and on ovalbumin-induced peritoneal mast cell degranulation in Wistar rats. Ethanol extracts of C.O.W.P., E.C.L., J.C.L., and X.A.L. at 100 mg/mL remarkably relaxed spontaneous contractions of isolated rabbit ileum. Greatest relaxation was obtained with X.A.L. Ethanol extracts of C.O.W.P., E.C.L., J.C.L., and X.A.L. statistically significantly (p ? 0.05) inhibited histamine-induced contractions of isolated guinea pig ileum. In addition, the four extracts statistically significantly inhibited (p ? 0.05) histamine-induced contraction of isolated guinea pig trachea. The ethanol leaves extracts of C. occidentalis and Jatropha curcas exhibited mast cell stabilizing effect in ovalbumin-induced rat peritoneal mast cell degranulation. However, Eucalyptus citriodora and Ximenia Americana did not protect against ovalbumin-induced rat peritoneal mast cell degranulation.
C.O.W.P., E.C.L., J.C.L., and X.A.L all possess broncho-relaxant activity, while only C.O.W.P. and J.C.L. exhibited mast cell stabilizing activity in laboratory animals thus supporting the traditional use of the plant in inflammatory and allergic conditions including asthma.

Keywords: Medicinal plant, North-western Nigeria, Airway smooth muscles, Broncho-relaxant, Mast cell stabilizer
Back to Articles

ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
Scopus citescore 0.3 (2020)

Indexing & Abstracting

citescore 0.3 (2020)

j-gate logo

International Innovative Journal Impact Factor

African Index Medicus

CAS

Index Copernicus International

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Crossref Content Registration logo

WorldCat Discovery Service

Geneva Foundation for Medical Education and Research