Diisooctyl Phthalate Isolated from Rourea mimosoides: A Partial PPAR? Agonist Potently Blocks Adipocyte Differentiation

Mohd I. Adenan1,2,3*, Tengku S. T. Muhammad4, Chuah B. Chung5, Mohd A. Aizuddin5, Zuriati Zahari2,3
1Universiti Teknologi MARA Pahang Branch, Bandar Tun Abdul Razak 26400, Jengka, Pahang Darul Makmur, Malaysia
2Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam 40450, Selangor Darul Ehsan, Malaysia
3Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Level 9, FF3 Puncak Alam Campus, Universiti Teknologi MARA, Puncak Alam 42300, Selangor Darul Ehsan, Malaysia
4Centre for Research and Innovation Management, Universiti Malaysia Terengganu, 21030, Kuala Terengganu, Terengganu, Malaysia
5Malaysian Institute of Pharmaceutical and Nutraceutical (IPharm), Blok 5A Halaman Bukit Gambir, 11700 Pulau Pinang, Malaysia

Corresponding Author: [email protected]; Tel: +60 192922020
Recieved Date: 15 May 2021; Accepted Date: 25 July 2022; Published Date: 03 September
Citation: Adenan MI, Muhammad TST, Chung CB, Aizuddin MA, Zahari Z. Diisooctyl Phthalate Isolated from Rourea mimosoides: A Partial PPARγ Agonist Potently Blocks Adipocyte Differentiation. Trop J Nat Prod Res. 2022; 6(8):1197-1202. http://www.doi.org/10.26538/tjnpr/v6i8.6
Copyright:
 © 2022 Adenan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at  Tropical Journal of Natural Product Research





ABSTRACT

Type II diabetes mellitus (T2DM) is a metabolic disorder due to the development of insulin resistant caused by the modification of insulin signalling, resulting in a reduction in glucose uptake in myocytes, hepatocytes, adipocytes, and elevation of blood glucose levels. Thiazolidinediones (TZDs) are medications used in the treatment of T2DM. The primary target of TZDs is the peroxisome proliferator-activated receptor-gamma (PPAR-?), a key regulator of adipogenesis and glucose homeostasis. In this study, extracts from Malaysian plants were tested in a screening platform which includes tests for adipocyte differentiation, insulin-stimulated glucose uptake and PPAR-? transactivation. A total of 122 plant extracts collected from Royal Belum Rainforest, Malaysia were tested on adipocyte differentiation, glucose uptake and PPAR-? transcription assays. Rourea mimosoides was found to inhibit the adipocyte differentiation and showed the ability to enhance the glucose uptake in C2C12 myoblast cells as well as active to promote the transcription of PPAR-?. A bioactive compound designated as compound 1 was isolated from this plant and was identified as Diisooctyl phthalate. The biological activities (adipocyte differentiation and PPAR-? transactivation) of this compound were demonstrated and compound 1 was found to possess the ability to trigger expression of PPAR-? in HepG2 cells.

Keywords: Type II Diabetes mellitus, PPAR-?, Adipocyte Differentiation, Rourea mimosoides, Diisooctyl phthalate.
Back to Articles

ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
Scopus citescore 0.3 (2020)

Indexing & Abstracting

citescore 0.3 (2020)

j-gate logo

International Innovative Journal Impact Factor

African Index Medicus

CAS

Index Copernicus International

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Crossref Content Registration logo

WorldCat Discovery Service

Geneva Foundation for Medical Education and Research