Histological and Biochemical Changes Associated with Blocking of Serotonin Receptor

Sami I. Abdullah1, Ayoub AH. Al-Bayti2, Mohammad J. Salih3, Marwan M. Merkhan4*
1Department of Anatomy, College of Veterinary Medicine, University of Kirkuk, Iraq
2Department of Medical Laboratory, College of Health and Medical Techniques, Kirkuk, Northern Technical University, Iraq
3Department of Clinical and Laboratory Science, College of Pharmacy, University of Anbar, Iraq
4Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Iraq

Corresponding Author: [email protected].iq ; Tel: +9647508662343
Recieved Date: 04 April 2022; Accepted Date: 29 August 2022; Published Date: 03 September
Citation: Abdullah SL, Al-Bayti AA, Mohammad J. Salih MJ, Merkhan MM. Histological and Biochemical Changes Associated with the Blockage of Serotonin Receptors in Sprague Dawley Albino Rats. Trop J Nat Prod Res. 2022; 6(8):1189-1192. http://www.doi.org/10.26538/tjnpr/v6i8.4
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© 2022 Abdullah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Schizophrenia is one of many psychotic disorders on a broad spectrum. The symptoms of psychosis resulting from schizophrenia and other spectrum disorders are treated with several medications, including aripiprazole, clozapine, risperidone, etc. However, these drugs are associated with adverse effects. This study was conducted to evaluate histological and biochemical changes linked to the blockage of serotonin receptors caused by risperidone and aripiprazole. Fifteen Sprague Dawley albino rats were divided into three groups of five rats each.  Group 1 served as the control and received a placebo (normal saline), Group 2 received risperidone (20 mg/kg/day), and Group 3 was given aripiprazole (10 mg/kg/day). After three months of treatment, a biochemical analysis of liver enzymes was performed, followed by a histological examination. The results revealed that the architecture of the liver cells appeared normal in all three groups. However, when risperidone and aripiprazole treatment groups were compared to the control group, histology was slightly altered. The level of glutamic oxaloacetic transaminase (GOT) in the control group increased slightly from 70 to 75 U/L. GOT levels increased from 80 to 120 U/L and 130 to 140 U/L in the aripiprazole and risperidone groups, respectively. A similar observation was made for the levels of glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) compared to the control group. The findings of this study found the levels of the biochemical enzymes within safe limits with the administration of aripiprazole and risperidone. However, patients using these drugs should always have routine laboratory examinations for liver enzyme tests.

Keywords: ALP, Biochemical changes, GOT, GPT, Histological changes, Liver, Serotonin.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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