Anti-Diabetic Potential of Silver (AgNPs) and Gold (AuNPs) Nanoparticles Synthesized Using an Aqueous Extract of Opuntia ficus indica Cladodes in Wistar Rats


Jelilat B. Ibikunle1,2, Elijah A. Adebayo1,2*, Abel M. Oke1,2, Jelili A. Badmus3, Taofeek A. Yekeen1, David B. Kehinde4


1Department of Pure and Applied Biology, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
2Microbiology and Biotechnology Laboratory, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso Nigeria
3Department of Biochemistry, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
4DaveJosh Global Resource Research Laboratory, Ogbomoso, Oyo State, Nigeria


Corresponding Author: [email protected]; [email protected] ; Tel: +2348038099092
Recieved Date: 18 May 2022; Accepted Date: 05 July 2022; Published Date: 04 August 2022
Citation: Ibikunle JB, Adebayo EA, Oke AM, Badmus JA, Yekeen TA, Kehinde DB. Anti-Diabetic Potential of Silver (AgNPs) and Gold (AuNPs) Nanoparticles Synthesized Using an Aqueous Extract of Opuntia Ficus indica Cladodes in Wistar Rats. Trop J Nat Prod Res. 2022; 6(7): 1152-1158 http://www.doi.org/10.26538/tjnpr/v6i7.19
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© 2022 Ibikunle et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Diabetes mellitus (DM) disease has become an increasingly important public health concern, due to its global occurrence and consequences. The study evaluated the anti-diabetic potential of silver (AgNPs) and gold (AuNPs) nanoparticles synthesized using an aqueous extract of Opuntia ficus indica (OFI) cladodes. The antidiabetic potential of OFI-extract, OFI-AgNPs, and OFI-AuNPs were investigated using sixty-three male Wistar rats consisting of seven (7) rats per group. Diabetes mellitus was induced by a single intraperitoneal injection of Streptozotocin (65 mg/kg b.w.) in groups DT5-DT9, while groups DT1-DT4 served as non-diabetic control groups. Glibenclamide (0.6 mg/kg b.w.)  was used as a standard drug for twenty-eight days of treatment. OFI-AgNPs and OFI extract increased the body weight significantly (P?0.05) in diabetic-treated rats and decreased the fasting blood glucose compared to DT5. The malondialdehyde levels of the liver and kidney (DT6 & DT8) were decreased compared with DT5. The activities of the enzymes were enhanced significantly (P<0.05) in diabetic rats treated with OFI-AgNPs and OFI-extract (DT6 & DT8) in comparison with DT5.
This finding demonstrated that OFI-AgNPs and OFI-extract protected the animals from diabetic complications associated with REDOX imbalances. Results showed that O. ficus indica can synthesize nanoparticles with potential as an anti-diabetic agent.

Keywords: Diabetes mellitus, Streptozotocin, Opuntia ficus indica, Albino rats, Nanoparticles.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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