Modulation of the Indices of Psychosis in Post-Convulsive Status Epilepticus Model: The Role of Proanthocyanidin-Rich Fraction

Opeyemi S. Osuntokun1,2*, Gbola Olayiwola 3, Kabiru I. Adedokun2, Kehinde A. Ademoye4, Adebiyi A. Adegoke5, Abiodun O. Ayoka4

1Department of Physiology, Faculty of Basic Medical Sciences, Federal University Oye-Ekiti Ekiti-State, Nigeria 
2Department of Physiology, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Nigeria
3Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
4Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University Ile-Ife, Nigeria
5Department of Anatomy, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Nigeria

Corresponding Author: [email protected]; Tel: +2347066106794
Recieved Date: 12 April 2022; Accepted Date: 21 July 2022; Published Date: 04 August 2022
Citation: Osuntokun OS, Olayiwola G, Adedokun KI, Ademoye KA, Adegoke AA, Ayoka AO. Modulation of the Indices of Psychosis in Post-Convulsive Status Epilepticus Model: the Role of Proanthocyanidin-Rich Fraction. Trop J Nat Prod Res. 2022; 6(7): 1146-1151.
© 2022 Osuntokun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Vitis vinifera seed contains high content of flavonoids particularly, proanthocyanidins. Experimental studies have demonstrated the anticonvulsant potency of Proanthocyanidins-Rich Fraction (PRF). However, this study was designed to evaluate the psychotropic activities of PRF in the post-convulsive status epilepticus (CSE). Six groups of juvenile rats were kindled for the seizure; 24 hours later, the survived rats were post-treated intraperitoneally with propylene glycol (PG), 0.1 or with graded doses of PRF (30 mg/kg, 20 mg/kg, or 10 mg/kg body weight [BW]) or diazepam (DZP) (5 mg/kg BW) for a period of one week. Three weeks after the last treatment, both the control and post-convulsed rats were examined for the markers of depression, anxiety, and muricidal actions. they were kept untreated but with access to feed and water for 21 days. There was a significant increase in the markers of anxiety-like behavior, locomotor activities, and depression-related behavior in the post-CSE rats compared with the control. The post-CSE rats exhibited impairment in societal interaction, evidenced by muricidal actions. Additionally, there was a significant increase in depression-related behavior, especially in the anhedonia test. However, all these aberrations were attenuated following PRF treatment, a result similar to what is obtained in the diazepam treatment group.
Conclusively, proanthocyanidins-rich-fraction from Vitis vinifera seed attenuates the markers of psychosis following CSE in juvenile Wistar rats.

Keywords: Convulsive status epilepticus, Anxiety, Depression, Social interaction, Proanthocyanidins.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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