Antioxidant and Antidiabetic Activities of Ethanol Extract of Ficus botryocarpa Miq. Fruit


Benjamart Cushnie1*, Autchara Promlaruk2, Chayapim Boonchoo2, Wanitchakorn Singban2, Thanawut Khaodee2, Boonyawat Boonradom2, and Pawitra Pulburt1


1Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, Thailand
2Undergraduate student, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, Thailand


Corresponding Author: [email protected]; Tel: +66956721145
Recieved Date: 27 May 2022; Accepted Date: 21 July 2022; Published Date: 04 August 2022
Citation: Cushnie B, Promlaruk A, Boonchoo C, Singban W, Khaodee T, Boonradom B, Pulburt P. Antioxidant and Antidiabetic Activities of Ethanol Extract of Ficus botryocarpa Miq. Fruit. Trop J Nat Prod Res. 2022; 6(7): 1119-1123 http://www.doi.org/10.26538/tjnpr/v6i7.13
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© 2022 Cushnie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Diabetes mellitus (DM) is a major public health concern worldwide. Poorly controlled diabetes can lead to hyperglycemia and serious complications, including macrovascular and microvascular diseases of the kidneys and eyes, and a variety of clinical neuropathies. There is evidence that serious complications are associated with increased generation of free radicals. Inhibition of alpha-amylase activity can be an effective strategy for controlling carbohydrate digestion and reducing postprandial hyperglycemia. This study aimed to investigate the in vitro antioxidant capacity and alpha-amylase inhibitory activity of Ficus botryocarpa fruit ethanol extract (FBFE). Antioxidant potential was determined using a radical scavenging capacity assay (2, 2-diphenyl-1-picrylhydrazyl; DPPH), 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid; ABTS), and ferric ion reducing power (FRAP) assays. The alpha-amylase inhibitory effect of the extract was investigated using 3,5 dinitrosalicylic (DNS) method. In the DPPH and ABTS assays, FBFE had IC50 values of 54.51±7.20 ?g/mL and 5.28±0.30 ?g/mL, respectively. In the FRAP assay, FBFE had FRAP value of 1.97±0.12 mM Fe2+/mg dried extract. In the DNS method, the highest inhibitory effect of the extract against alpha-amylase was 97.65±5.27% at 50 ?g/mL, with a half maximal inhibitory concentration (IC50) value of 6.22±2.31 ?g/mL. Therefore, it can be concluded that the ethanol fruit extract of Ficus botryocarpa demonstrated high antioxidant capacity and alpha-amylase inhibitory activity. This finding may justify its traditional use in the treatment of diabetes mellitus

Keywords: Diabetes mellitus, Ficus botryocarpa Miq fruit, Antioxidant, Alpha-amylase inhibition
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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