Antidiabetic Activity of Medicinal Plants: An Updated Overview of Streptozotocin and Alloxan-Induced Diabetic Models

Kavya Yedelli and Ramachandran K. Pathangi*
Sri Ramaswamy Memorial College of Pharmacy, Sri Ramaswamy Memorial University, Chennai, India


Corresponding Author: [email protected]; Tel: 7010102596
Recieved Date: 21 December 2021; Accepted Date: 1 July 2022; Published Date: 04 August 2022
Citation: Yedelli K and Pathangi RK. Antidiabetic Activity of Medicinal Plants: An Updated Overview of Streptozotocin and Alloxan-induced Diabetic Models. Trop J Nat Prod Res. 2022; 6(7): 1047-1056 http://www.doi.org/10.26538/tjnpr/v6i7.3
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© 2022 Yedelli and Pathangi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Insulin resistance (type 2 diabetes mellitus) leads to the development of hyperglycemia.  The present review was aimed at providing an overview of current traditional antidiabetic medicinal plants evaluated by streptozotocin and alloxan. A total of seventy medicinal plants were mentioned with antidiabetic activities in the streptozotocin-induced diabetic model (thirty-six), and alloxan-induced diabetic model (thirty-four). Also, the presence of active ingredients, dose, and significance of antidiabetic action of the medicinal plants were evaluated. In this review, the herbal plants for the treatment of diabetes in the majority of the plants found in Nigeria have been highlighted, and the efficacy of the seventy herbs in the management of diabetes has been evaluated. Diabetes is treated with approximately 40% of medicinal plant leaves. Based on the findings of this review, it is possible to use herbs as adjuvant therapies in the management and treatment of diabetes. Further research into the isolation of phytochemicals and their mechanisms of action will lead to the discovery of newer antidiabetic agents

Keywords: Alloxan-induced models, Antidiabetic activity, Medicinal plants, Streptozotocin-induced model, Traditional uses.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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