The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in Xenobiotic-Induced Liver Toxicity: A Narrative Review

Jamal-Deen I. Tiiba1*, Mohammed B. Sule2, Peter U.βAhmadu5, Alhassan Naamawu3,βMemunatu Fuseini3,βAnechamβRaymond4,βEvelyn Osei-Amoah6, PeterβC. Bobrtaa7, Peter P. Bacheyie4, MohammedβAbdulai4, Issah Alidu4,βAhmedβAlhassan4, Hamid G. Jemilatu4, Abukari Yussif4, TayawnβP. Tereku4, Abigail A. Sakyi4, TitusβN. Yeng4, Sanda A. Aziz4,βAbdul-Hafiz Mankana4, Hussein A.Wahab4,βAbdul-Kudus W. Abdallah4, Kpankpari S.Mwininyaabu4, MartinβO.βKuffour4,βEstherβO. Boateng4, Bernard Owusu-Achiaw4, Nkukar J. Eyulaku4

1Pharmacology Department, Faculty of Pharmaceutical Sciences, AhmaduβBello University, Zaria, Nigeria
2Pharmacology Department, University for Development Studies, Ghana
3IntensiveβCare Unit, Tamale Teaching Hospital, Ghana
4LaboratoryβDepartment,TamaleβTeaching Hospital, βGhana
5Pharmacology & Toxicology Department, National Institute for Pharmaceutical Research & Development, Idu, Abuja Nigeria
6OncologyβUnit, TamaleβTeaching Hospital, Ghana
7Department of Medicine, Tamale Teaching Hospital, Ghana

Corresponding Author: [email protected] ; Tel: +2348089243661
Recieved Date: 6 April 2020; Accepted Date: 30 June 2022; Published Date: 04 August 2022
Citation: Tiiba JDI, Sule MB, Ahmadu PU, Naamawu A, Fuseini M, Raymond A, Osei-Amoah E, Bobrtaa PC, Paul PB,Abdulai M,Alidu I, Alhassan A,Jemilatu HG, Yussif A,Tereku TP,Sakyi AA,Yeng TN, Aziz SA,  Mankana AH, Wahab HA, Abdallah AKW,Mwininyaabu KS, Kuffour MO, Boateng EO, Achiaw BO, Eyulaku NJ. The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in Xenobiotic-induced Liver Toxicity: A  Narrative  Review.  Trop J Nat Prod Res. 2022; 6(7): 1010-1018. http://www.doi.org/10.26538/tjnpr/v6i7.1
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© 2022 Tiiba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Acute?liver?injury (ALI) is?a life-threatening?medical?emergency?which?involves multiple organ ?systems. The synthetic, metabolic?and?excretory?functions?of?the?liver are ?severely impaired in ALI.?ALI?is defined as?a rapid development of ALI with encephalopathy?in patients who previously?had?normal?liver functions. Drug-induced hepatotoxicity?or drug-induced liver injury (DILI)?is?an acute or?chronic?response to a?natural?or?manufactured compound. In the US, it ?is?the leading?cause?of acute liver?failure?episodes (13-16%). ?The development of these disorders reflects complex pathological ?processes?in?which ?the oxidative ?stress caused by reactive oxygen species (ROS)?and reactive nitrogen species (RNS) play?pivotal roles. Alpha?lipoic acid (ALA), which plays an essential role as an antioxidant has drawn considerable attention for use in managing liver disorders

Keywords: Alpha lipoic acid, Hepatoprotective activity, Oxidative stress.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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