The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in Xenobiotic-Induced Liver Toxicity: A Narrative Review

Jamal-Deen I. Tiiba¹*, Mohammed B. Sule², Peter U.βAhmadu⁵, Alhassan Naamawu³,^βMemunatu Fuseini³,^βAnecham^βRaymond⁴,^βEvelyn Osei-Amoah⁶, Peter^βC. Bobrtaa⁷, Peter P. Bacheyie⁴, Mohammed^βAbdulai⁴, Issah Alidu4,βAhmedβAlhassan4, Hamid G. Jemilatu4, Abukari Yussif4, Tayawn^βP. Tereku⁴, Abigail A. Sakyi4, TitusβN. Yeng4, Sanda A. Aziz4,βAbdul-Hafiz Mankana⁴, Hussein A.Wahab4,βAbdul-Kudus W. Abdallah4, Kpankpari S.Mwininyaabu⁴, Martin^βO.βKuffour⁴,βEstherβO. Boateng4, Bernard Owusu-Achiaw4, Nkukar J. Eyulaku⁴

¹Pharmacology Department, Faculty of Pharmaceutical Sciences, AhmaduβBello University, Zaria, Nigeria

²Pharmacology Department, University for Development Studies, Ghana

³IntensiveβCare Unit, Tamale Teaching Hospital, Ghana

⁴LaboratoryβDepartment,TamaleβTeaching Hospital, βGhana

⁵Pharmacology & Toxicology Department, National Institute for Pharmaceutical Research & Development, Idu, Abuja Nigeria

⁶OncologyβUnit, TamaleβTeaching Hospital, Ghana

⁷Department of Medicine, Tamale Teaching Hospital, Ghana

Corresponding Author: [email protected] ; Tel: +2348089243661

Recieved Date: 6 April 2020; Accepted Date: 30 June 2022; Published Date: 04 August 2022

Citation: Tiiba JDI, Sule MB, Ahmadu PU, Naamawu A, Fuseini M, Raymond A, Osei-Amoah E, Bobrtaa PC, Paul PB,Abdulai M,Alidu I, Alhassan A,Jemilatu HG, Yussif A,Tereku TP,Sakyi AA,Yeng TN, Aziz SA,  Mankana AH, Wahab HA, Abdallah AKW,Mwininyaabu KS, Kuffour MO, Boateng EO, Achiaw BO, Eyulaku NJ. The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in Xenobiotic-induced Liver Toxicity: A  Narrative  Review.  Trop J Nat Prod Res. 2022; 6(7): 1010-1018. http://www.doi.org/10.26538/tjnpr/v6i7.1

Copyright:

© 2022 Tiiba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at  Tropical Journal of Natural Product Research

ABSTRACT

Acute?liver?injury (ALI) is?a life-threatening?medical?emergency?which?involves multiple organ ?systems. The synthetic, metabolic?and?excretory?functions?of?the?liver are ?severely impaired in ALI.?ALI?is defined as?a rapid development of ALI with encephalopathy?in patients who previously?had?normal?liver functions. Drug-induced hepatotoxicity?or drug-induced liver injury (DILI)?is?an acute or?chronic?response to a?natural?or?manufactured compound. In the US, it ?is?the leading?cause?of acute liver?failure?episodes (13-16%). ?The development of these disorders reflects complex pathological ?processes?in?which ?the oxidative ?stress caused by reactive oxygen species (ROS)?and reactive nitrogen species (RNS) play?pivotal roles. Alpha?lipoic acid (ALA), which plays an essential role as an antioxidant has drawn considerable attention for use in managing liver disorders