Secondary Metabolites from the leaves and stems of Leonotis nepetifolia (Lamiaceae)

Yomica Powder-George
Department of Chemistry, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Corresponding Author: [email protected]; Tel: +1 868 775 6194
Recieved Date: May 17, 2018; Accepted Date: June 04, 2018; Published Date: 07 June 2018
Citation: Powder-George Y. Secondary Metabolites from the leaves and stems of Leonotis nepetifolia (Lamiaceae). Trop J Nat Prod Res. 2018; 2(6):293-296.
Copyright: © 2018 Powder-George. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Leonotis nepetifolia (L.) R. Br. (Lamiaceae), commonly known as ‘Shandilay’, is well-known and widely used in Trinidadian ethnomedicine as well as in different countries for the treatment of various ailments. Biological activities for the plant and many phytoconstituents have been reported; however, the plant species located in Trinidad is yet to be investigated for its chemical constituents. This study was conducted to investigate the secondary metabolites that may be responsible for the observed traditional medicinal uses of the plant. A phytochemical investigation of the chloroform and 1-butanol fractions of the crude methanol extract of the leaves and stems from L. nepetifolia resulted in the isolation of 7 compounds which were identified as Stigmasterol-3-O-?-D-glucoside (1), trans-caffeic acid (2), trans-p-coumaric acid (3), Apigenin-7-O-?-D-glucoside (4), Uridine (5), Luteolin-7-O-?-D-glucoside (6) and Adenosine (7). Isolation of the seven compounds was performed by a combination of silica gel column chromatography and size exclusion column chromatography on Sephadex® LH-20. The chemical structures of these compounds were determined by comprehensive analyses of their 1H and 13C NMR, COSY, HSQC, and HMBC spectroscopic data, and HREIMS mass spectrometric data, as well as comparison of spectral data with that reported in the literature. To the best of the author’s knowledge, this is the first report on the isolation of compounds 1–7 from L. nepetifolia, compounds 1-3 and 5 from the genus Leonotis and compound 7 from the Lamiaceae family. These reported bioactive constituents might be responsible for some of the observed biological activities of the plant Leonotis nepetifolia.

Keywords: Leonotis nepetifolia, Shandilay, Lamiaceae, Isolation, Structure elucidation, Trinidad
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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