Gastroprotective Effect of Methanol extracts of Sphenocentrum jollyanum Pierre and Curculigo pilosa (Schumach. & Thonn.) Engl.  in Wistar Rats

Idayat A. Akinwumi1, Mubo A. Sonibare1*, Adeola T. Salami2

1 Pharmacognosy Department, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
2 Physiology Department, College of Medicine, University of Ibadan, Ibadan, Nigeria

Corresponding Author: [email protected]; Tel: +2348134901273
Recieved Date: 30 January 2022; Accepted Date: 29 April 2022; Published Date: 03 May
Citation: Akinwumi IA, Sonibare MA, Salami AT. Gastroprotective Effect of Methanol extracts of Sphenocentrum jollyanum Pierre and Curculigo pilosa (Schumach. & Thonn.) Engl.  in Wistar Rats. Trop J Nat Prod Res. 2022; 6(4): 637-644 http://www.doi.org/10.26538/tjnpr/v6i4.27
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© 2022 Akinwumi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Curculigo pilosa (Schumach. & Thonn.) Engl.  and Sphenocentrum jollyanum Pierre are commonly used plants in traditional medicine in the management of several ailments. The rhizomes of C. pilosa and seeds of S. jollyanum are traditionally used for treating gastrointestinal diseases. There is need to justify the medicinal claim of the selected plants as having anti-ulcerogenic activity to ensure efficacy and safety. In this study, the gastroprotective effect of methanol extracts of Sphenocentrum jollyanum Pierre and Curculigo pilosa (Schumach. & Thonn.) Engl.  in Wistar Rats was evaluated. Lorkes method was used for the toxicity study. Animals were grouped and pre-treated with varied doses of extracts and standard drug (cimetidine) for 7 days and gastric ulcer was induced experimentally using 40 mgkg-1 b.w. indomethacin on day 8 of treatment. Gastric ulcer index, biochemical, and histological evaluation were investigated. The LD50 of both extracts were > 5000 mgkg-1 b.w. as no lethality was recorded up to this level. Cimetidine (100 mgkg-1 b.w.), C. pilosa (50 mgkg-1 b.w.), and S. jollyanum (200 mgkg-1 b.w.) gave inhibitions of 97.5%, 82.5%, and 72.5% respectively, compared to 0% of the ulcer untreated. A significant increase in antioxidant parameters was observed compared with ulcer untreated group. Histological evaluation of the gastric tissue from ulcerated untreated group revealed severe lesions, which were ameliorated in C. pilosa, S. jollyanum extracts and cimetidine treated groups. Curculigo pilosa and Sphenocentrum jollyanum extracts demonstrated gastroprotective activity probably via increased antioxidant activities against indomethacin-induced gastric ulcer thereby justifying their ethno-medicinal claim.

Keywords: Gastric ulcer, Gastroprotection, Indomethacin, Curculigo pilosa, Sphenocentrum jollyanum, Histopathology,
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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