Estimation of Oxidative Stress Enzymes and Vitamins Levels in Acute Lymphocytic Leukemia Patients in the Governorate of Basrah, Iraq

Ala’a A.H. Al-Maliki* and Abbas D.M. Al-Maliki
Department of Chemistry, College of Education for pure sciences, University of Basrah, 61004 Basrah, Iraq

Corresponding Author: [email protected]; Tel: 009647703217803
Recieved Date: 05 March 2022; Accepted Date: 11 April 2022; Published Date: 03 May
Citation: Al-Maliki and Al-Maliki. Estimation of Oxidative Stress Enzymes and Vitamins Levels in Acute Lymphocytic Leukemia Patients in the Governorate of Basrah, Iraq. Trop J Nat Prod Res. 2022; 6(4): 542-545 http://www.doi.org/10.26538/tjnpr/v6i4.13
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© 2022 Al-Maliki and Al-Maliki. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Acute lymphocytic leukemia (ALL) is a multi-disease that affects most people, especially children. The present research was conducted to estimate some oxidative stress enzyme and antioxidant vitamin levels in the blood serum of Iraqi ALL patients in relation to sex and age. In this study, 100 patients (57 men and 43 women) with ALL disease and 80 healthy subjects (43 men and 37 women) ranging in age from 1 to 17 years were enrolled. Venous blood was clinically collected from both the ALL patients and healthy individuals. Blood serum levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were tested using the enzyme-linked immunosorbent assay. Vitamins A, E, and C were also assessed. The amount of catalase (CAT) in the sample was measured using a spectrophotometric technique. The results revealed that the levels of GPx, SOD, and CAT decreased significantly (P<0.0001) in ALL patients compared to the control group. Also, the levels of vitamins A, E, and C decreased significantly (P<0.0001) in ALL patients compared to the control   group.  The findings of this study revealed that GPx, SOD, and CAT enzymes, as well as vitamins A, E, and C are considered key biochemical markers of ALL disease.

Keywords: Acute lymphocytic leukemia, Catalase, Glutathione peroxidase, Superoxide dismutase, Vitamin A, Vitamin E
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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