Evaluation of the Therapeutic Effect of Curcumin Phytosomes on Streptozotocin-Induced Diabetic Rats

Wasel Alhabashneh1, Khaled M. Khleifat2,1, Moath Alqaraleh 3*, Laila Al-Omari4, Nidal Qinna5, Muhamad O. Al-limoun1, Haitham Qaralleh6, Husni S. Farah2, Talal Alqais2
1Department of Biological Sciences, Mutah University, Al-Karak, Jordan
2Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan
3Pharmacological and Diagnostic Research Center (PDRC), Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Al-Ahliyya Amman University
4Department of Medical Laboratory, Faculty of Allied Medical Sciences, Zarqa University, Jordan
5Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan
6Department of Medical Laboratory Sciences, Faculty of Science, Mutah University, Mutah, Karak, 61710, Jordan

Corresponding Author: [email protected]; Tel: +(009620795038456)
Recieved Date: 22 February 2022; Accepted Date: 20 April 2022; Published Date: 03 May
Citation: Alhabashneh W, Khleifat KM, Alqaraleh M, Al-Omari L, Qinna N, Al-limoun MO, Qaralleh H, Farah HS, Alqais T. Evaluation of the Therapeutic Effect of Curcumin Phytosomes on Streptozotocin-induced Diabetic Rats. Trop J Nat Prod Res. 2022; 6(4): 529-536 http://www.doi.org/10.26538/tjnpr/v6i4.11
© 2022 Alhabashneh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Diabetes Mellitus (DM) has been described as a metabolic disorder that results in chronic high blood sugar level. However, it is difficult to evaluate the effectiveness of natural products such as curcumin on diabetes and its complications, due to the low intestinal bioavailability and the low systemic absorption rate. The study evaluated the efficacy of the phytosome in its ability to enhance the absorption of curcumin and thus its effect on blood sugar level and lipid profile in streptozotocin (STZ)-nicotinamide-induced diabetic rats. Curcumin and combination of curcumin and phytosomes (Cur-P) were administered orally at 150 and 250 mg/kg, respectively, to streptozotocin (STZ)-nicotinamide induced DM rats. Metformin was used as a positive control. The blood glucose level and lipid profile were monitored for 21 days. The results showed a clear decline in the levels of blood glucose, cholesterol, triglycerides, and the low-density lipoprotein (LDL), cholesterol, in addition to a significant rise in the high-density lipoprotein (HDL). The hypoglycemic and hypolipidemic effects caused by treatment with Cur-P were higher than those treated with Curcumin alone at the same dose, indicating that the phytosomes enhances the potential of absorption and bioavailability of Curcumin. The findings suggest that Cur-P may have a potential therapeutic effect on diabetes through enhancing the potential of absorption and bioavailability of curcumin.

Keywords: Diabetes mellitus, Curcumin, phytosomes, hypolipidemic, hypoglycemic 
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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