Biochemical and Hepatoprotective Effects of Gangronema latifolium Extract on Alloxan-Induced Diabetic Rats

Ikechukwu K. Chukwudozie1,2* and Ifeoma M. Ezeonu1  
1Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria
2Department of Clinical Medicine, School of Medicine, Jiangsu University, China








Corresponding Author: [email protected]g; Tel: +2348038926486
Recieved Date: 05 October 2021; Accepted Date: 28 January 2022; Published Date: 03 January
Citation: Chukwudozie IK and Ezeonu IM. Biochemical and Hepatoprotective Effects of Gangronema latifolium Extract on Alloxan-Induced Diabetic Rats. Trop J Nat Prod Res. 2022; 6(1):144-149 http://www.doi.org/10.26538/tjnpr/v6i1.23
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© 2022 Chukwudozie and Ezeonu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Diabetes mellitus is a chronic metabolic disease associated with hyperglycemia, dyslipidemia, and hepatocellular damage. Gongronema latifolium has been widely explored in ethnomedicine for the treatment and management of various disorders. The biochemical, hepatoprotective, and histological effects of aqueous-ethanolic leaf extract of G. latifolium (Family: Asclepiadaceae) in alloxan-induced diabetic rats were investigated in this study. Thirty (30) juvenile male Wistar rats were placed into six groups, each with five rats: Normal rats made up Group 1, while diabetic rats in Groups 2–4 were given 200, 400, and 800 mg/kg body weight of aqueous-ethanolic leaf extract, respectively; diabetic rats in Group 5 were given a standard anti-diabetic drug (0.2 mg/kg glibenclamide), and diabetic rats in Group 6 were left untreated. When compared to control rats, alloxan-induced diabetic rats showed a significant (p ? 0.05) rise in liver enzymes, low density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), and fasting blood glucose (FBG), but a significant (p ? 0.05) decrease in high density lipoprotein (HDL). The alterations in the following parameters were returned to normal levels when the diabetic rats were administered G. latifolium extract. At the end of the experimental period, the rats were sacrificed, and each experimental groups liver tissues were removed and used for histopathological examinations. When compared to the normal control and treatment groups, which had normal liver histological features, the diabetes groups histology showed cytoplasmic deterioration. The results indicate that G. latifolium may serve as a remedy for the management of diabetes.

Keywords: Gongronema latifolium, Diabetes, Wistar rats, Alloxan, Liver.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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