Scopolamine-Induced Alzheimer’s Disease in Wistar Rats: Aqueous Talinum Triangulare Potency on the Hippocampal Nissl Bodies and Long-Term Learning and Memory

Eru M. Eru1*, Sadeyeng E. Anani1, Samson O. Paulinus2, Otu E. Mesembe1, Kelechi C. Uruakpa1, Nsikak M. Umoh1, Michael E. Oku1, Mfon I. Akpaso1, Anozeng O. Igiri1
1Department of Anatomical Sciences, University of Calabar, Nigeria
2Department of Radiography and Radiological Science, University of Calabar, Nigeria






Corresponding Author: [email protected]; Tel: +2347065560843
Recieved Date: 11 November 2021; Accepted Date: 31 December 2021; Published Date: 03 January
Citation: Eru EM, Anani SE, Paulinus SO, Mesembe OE, Uruakpa KC, Umoh NM, Oku ME, Akpaso MI, Igiri AO. Scopolamine-Induced Alzheimer’s Disease in Wistar Rats; Aqueous Talinum Triangulare Potency on the Hippocampal Nissl Bodies and Long-Term Learning and Memory. Trop J Nat Prod Res. 2022; 6(1):117-122 http://www.doi.org/10.26538/tjnpr/v6i1.19
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© 2022 Eru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Alzheimers disease is a chronic neurodegenerative ailment represented clinically by studying and recalling alteration by pathologies such as intracellular neurofibrillary tangles and extracellular amyloid plaques. The study aimed at elucidating the potency of aqueous extract of Talinum triangulare leaves on the hippocampal neurons as well as assessing the long term learning and memory of scopolamine-induced Alzheimers type rats. Fifty-four Wistar rats (180-200 g) were used for the study; thirty rats were grouped into five groups; A, B, C, D and E while twenty-four rats were used to establish LD50. Alzheimers type cognitive dysfunction was intraperitoneally (ip) induced with scopolamine hydrobromide (SHB) (1 mg/kg, ip) for seven days in groups B-E prior to the oral administration of the extract (875 and 1750 mg/kg and donepezil (1 mg/kg), followed by the Morris water maze test and histochemical staining process (Cresyl Fast Violet stains). The results revealed that the Nissl bodies were mild to moderately stained indicating protein synthesis. The enhancement of learning and memory were also seen in the treated groups compared to the untreated group. The ameliorative potentials may be attributed to the antioxidative properties of Talinum triangulare leaves which restored cells, increased protein synthesis hence, leading to enhanced learning and memory. From the above results, Talinum triangulare has ameliorative effect on the hippocampus of scopolamine-induced Alzheimer’s type cognitive dysfunction in Wistar rats.

Keywords: Alzheimers disease, Hippocampus, Learning and Memory, Nissl bodies, Talinum triangulare.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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