Cardio-Protective Effect of Hunteria umbellata Seed: Experimental and In-silico Approaches

Adetoun E. Morakinyo1*, Femi E. Omoniyi1, Samuel C. Nzekwe1, Abel K. Oyebamiji2, Joy M. Adelowo2, Sulaiman A. Lawal 1, Angel A. Olumade 1, Elijah O. Olopade1, Temitope A. Oyedepo1*
1Department of Biochemistry, Adeleke University, Ede, Osun state, Nigeria
2Department of Basic Sciences, Adeleke University, Ede, Osun state, Nigeria





Corresponding Author: [email protected]; [email protected]; Tel: +234-7033744184; +234-8035838269
Recieved Date: 30 September 2021; Accepted Date: 30 January 2022; Published Date: 03 January
Citation:
Morakinyo A.E, Omoniyi F.E., Nzekwe S.C., Oyebamiji A.K, Adelowo J.M., Lawal S. A., Olumade A.A. , Olopade E.O., Oyedepo T.A. Cardio-Protective Effect of Hunteria umbellata Seed: Experimental and In-silico Approaches. Trop J Nat Prod Res. 2022; 6(1):87-94
http://www.doi.org/10.26538/tjnpr/v6i1.16
Copyright:
© 2022 Morakinyo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Cardiotixicity is one of the main causes related to sudden death in the world. The study investigated  the ameliorative potential of Hunteria umbellata against isoproterenol (ISO)-induced  cardiotoxicity using experimental and in-silico approaches. The ethanol extract of H. umbellata was prepared, phytochemically screened and quantified. In vitro antioxidant potential of the extract was also carried out. Male Wistar rats (30) were randomly and equally grouped into five and used for this study. After administration of the extract, the rats were sacrificed. Thereafter, the cardiac toxicity biomarkers (CK-MB, LDH, AST) and lipid profiles [Triglycerides (TG), Total cholesterol (TC) and High-density cholesterol (HDL-c)] were estimated from the blood plasma. Five molecular compounds from H. umbellata seed were selected based on their percentage yield and they were subjected to optimization using Spartan 14. The optimized compounds were docked against ?1-adrenergic receptor (PDB ID: 2ycw). Data obtained was analyzed using standard descriptive and inferential statistics. Pre-treatment with the extract caused a significant decrease in the levels LDH, AST, TC and TG with the most apparent effect at 100 mg/kg bwt. There was no significant difference in the activity of CK-MB. It was observed that compound (A), (C) and (E) inhibited ?1-adrenergic receptor than the referenced drug. In conclusion, H. umbellata exhibited ameliorative effects against ISO-induced myocardial damage, suggesting preliminary anti-dyslipidemia abilities possibly due to high phenolic and flavonoid contents.

Keywords: Cardio-protective, Hunteria umbellata, Propanalol, Phytochemicals.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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