Effects of Traditional Thai Herbal Formulations in Patients with Obesity and Borderline Hyperlipidemia - A Preliminary Pilot Study

Thanyaluck Siriyong1,2,*, Thanyamon Boonya-arunnate1, Koravee Ninbodee1, Thanaphat  Kaewmuean1, Thanchanok Mettriyasakul1, Kanokwan Jawang1 , Pipatpon Thongmongkol1 , Somporn Chanwanitsakul3, Komjak Kaewnoi3, Benjaporn Buachum4, Dennapa Saeloh2,5, Chayanee Noosak2,6, Supayang P. Voravuthikunchai2,6
1Traditional Thai Medical Research and Innovation Center, Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
2Excellent Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Songkhla 90110, Thailand
3Traditional Thai Medicine Hospital, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
4Tambon Khlong Chanon Health Promotion Hospital, Wiang Sa, Surat Thani, 84190, Thailand
5Faculty of Medical Technology, Prince of Songkla University, Songkhla 90110, Thailand.
6Division of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand



Corresponding Author: [email protected]; Tel: ++66-74-282722
Recieved Date: 07 October 2021; Accepted Date: 18 January 2022; Published Date: 03 January
Citation: Siriyong T, Boonya-arunnate T, Ninbodee K, Kaewmuean T, Mettriyasakul T, Jawang K, Thongmongkol P, Chanwanitsakul S, Kaewnoi K, Buachum B, Saeloh D, Noosak C, Voravuthikunchai SP. Effects of Traditional Thai Herbal Formulations in Patients with Obesity and Borderline Hyperlipidemia - A Preliminary Pilot Study. Trop J Nat Prod Res. 2022; 6(1):29-33 http://www.doi.org/10.26538/tjnpr/v6i1.6
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© 2022 Siriyong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Traditional Thai herbal medicine as an alternative treatment has a long history of usage and provides therapeutic options for dyslipidemia. This study aimed to demonstrate the effects of Thai herbal formulations including hypolipidemic and laxative formulations in patients with obesity and borderline hyperlipidemia.  Pre-post pilot studies were conducted in patients with obesity (healthy volunteers aged 18-40 years old with body mass index (BMI) ? 30 kg/m2) (n = 7) and borderline hyperlipidemia (adults aged 25-55 years old with one of the following factors related to dyslipidemia: LDL > 135 mg and < 190 mg/dL; HDL < 40 mg/dL; total cholesterol > 200 mg/dL; triglyceride > 150 mg/dL) (n = 6). All participants consumed two capsules of hypolipidemic formulation (1000 mg) twice daily after breakfast and dinner and 30 mL of laxative formulation twice weekly before bedtime for three months. Outcome measurements including body weight, BMI, waist and hip circumference, serum lipid parameters, toxicity tests were assessed at baseline and end of treatment. Hypolipidemic and laxative formulations slightly reduced total cholesterol and low-density lipoprotein levels and were safe in patients with obesity. Furthermore, both formulations significantly decreased low-density lipoprotein levels (p < 0.05), slightly reduced total cholesterol levels and were safe in patients with borderline hyperlipidemia.  Furthermore, both formulations significantly decreased low-density lipoprotein levels (p < 0.05), slightly reduced total cholesterol levels and were safe in patients with borderline hyperlipidemia. The findings revealed that traditional Thai herbal formulations significantly reduced low-density lipoprotein levels 

Keywords: Hypolipidemic formulation, Laxative formulation, Obesity, Dyslipidemia 
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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