Acacetin and Chrysoeriol: A Short Review of the Chemistry, Plant Sources, Bioactivities and Structure-Activity Relationships of these Methylated Flavones

Eric W. C. Chan1*, Siu K. Wong2, Hung T. Chan3
1Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia 
2Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia 
3Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan

Corresponding Author: [email protected]; [email protected] ; Tel: +603-9101 8880
Recieved Date: 23 September 2021; Accepted Date: 10 December 2021; Published Date: 03 January
Citation: Chan EWC, Wong SK, Chan HT. Acacetin and Chrysoeriol: A Short Review of the Chemistry, Plant Sources, Bioactivities and Structure-Activity Relationships of these Methylated Flavones. Trop J Nat Prod Res. 2022; 6(1):1-7   http://www.doi.org/10.26538/tjnpr/v6i1.1
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© 2022 Chan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Flavonoids are plant secondary metabolites that are well-known for their bioactivities. In this article, the chemistry, plant sources, bioactivities and structure-activity relationships of acacetin (ACT) and chrysoeriol (CSE) are reviewed. Of these two flavones, only ACT has been reviewed but not CSE. Sources of information cited were from Google Scholar, PubMed, PubMed Central, Science Direct, Web of Science, J-Stage, PubChem and Directory of Open Access Journals (DOAJ). The criteria used for selection of articles are based on topics rather than period of coverage, although recent references accord higher priority. Flavones, a class of flavonoids, have a C2–C3 double bond and a 4-carbonyl group but lack the C3 hydroxyl group at ring C. ACT and CSE are lesser-known methylated flavones with hydroxyl groups at C5 and C7 of ring A. The methoxy group of ACT is at C4 while that of CSE is at C3. Found in many plant species, ACT and CSE have generated much research interest because of their diverse pharmacological activities, notably, their anti-cancer properties. The anti-cancer effects and molecular mechanisms of ACT towards lung, liver, gastric, prostate, breast and squamous cancer cells including leukaemia have been reported. Studies have shown that CSE inhibited breast, lung and pancreatic cancer cells including myeloma. Other bioactivities and structure-activity relationships of ACT and CSE are also briefly mentioned. Some areas for further research are suggested.

Keywords: Acacetin, Chrysoeriol, Methylated Flavones, Cytotoxicity, Structure-Activity Relationships.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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