Antidiabetic and Antidyslipidemic Activities of Dryopteris Filix-Mas Methanol Leaf Extract in Alloxan-Induced Diabetic Rats

Ejiro P. Awhin^1*, Alfred I. Ajoh¹, Blessing Erutere²

¹Department of Medical Biochemistry, Delta State University, Abraka, Nigeria

²School of Midwifery, University of Benin Teaching Hospital, Benin, Edo State, Nigeria

Corresponding Author: [email protected]; [email protected]; Tel: +2348103861380

Recieved Date: 25 October 2021; Accepted Date: 24 December 2021; Published Date: 04 January

Citation: Awhin EP, Ajoh AI, Erutere B. Antidiabetic and Antidyslipidemic Activities of Dryopteris Filix-Mas Methanol Leaf Extract in Alloxan-Induced Diabetic Rats. Trop J Nat Prod Res. 2021; 5(12): 2170-2173 http://www.doi.org/10.26538/tjnpr/v5i12.22

Copyright:

© 2021 Awhin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Diabetes mellitus, a chronic metabolic disease with significant morbidity and mortality, has been associated with changes in lipid profile. Dryopteris filix-mas has been widely explored in treatment and management of various disorders. The antidiabetic and antidyslipidemic effects of Dryopteris filix-mas in alloxan-induced diabetic rats were investigated in Wistar rats. Thirty (30) adults male Wistar rats used were grouped into: 1 (Normal control); 2 (Untreated alloxan induced-diabetic rats); 3 (Diabetic rats administered 500mg/kg metformin); 4 (Diabetic rats administered 100mg/kg Dryopteris filix methanol leaf extract). 5 (Diabetic rats administered 250mg/kg Dryopteris filix methanol leaf extract); 6 (Diabetic rats administered 500 mg/kg Dryopteris filix methanol leaf extract). The rats were sacrificed after 21 days. The serum was used for biochemical assay of glucose, cholesterol, triglyceride, high density lipoprotein (HDL) and low-density lipoprotein (LDL), using standard procedures. Dryopteris filix leaf extract significantly (p<0.05) reduced blood glucose levels in rats after initial increase in glucose following diabetes induction. Induction of diabetes in rats significantly (p<0.05) increased serum cholesterol, triglyceride and LDL levels, while significantly reducing HDL levels in diabetic rats. However, administration of varying doses of Dryopteris filix-mas extract significantly (p<0.05) decreased levels of cholesterol, triglyceride and LDL with corresponding increase in level of HDL. The observed changes compared well with the group administered metformin. The methanol leaf extract of Dryopteris filix-mas, thus, improved serum lipid profile, in diabetic rats, along with having antihyperglycemic activity.