Stress Responses and Alteration in Membrane-Bound Phosphatase Activities in Wistar Rats Treated with Adrenaline: The role of Senna occidentalis Extract

Hassan Fatima^1,2*, Owolabi A. Olumuyiwa², Anigo .M. Kola², Ibrahim Sani², Umar I. Alhaji²

¹Department of Plant Sciences, Institute for Agricultural Research, Ahmadu Bello University, Zaria, Nigeria

²Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria

Corresponding Author: [email protected]; Tel: 08059662455

Recieved Date: 05 March 2021; Accepted Date: 23 December 2021; Published Date: 04 January

Citation: Fatima H, Owolabi OA, Anigo KM, Ibrahim S, Umar IA. Stress Responses and Alteration in Membrane-Bound Phosphatase Activities in Wistar Rats Treated with Adrenaline: The role of Senna occidentalis Extract. Trop J Nat Prod Res. 2021; 5(12): 2127-2132 http://www.doi.org/10.26538/tjnpr/v5i12.14

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© 2021 Fatima et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

The cardiotoxic effect of Adrenaline has been recounted in several studies but its effect on membrane-bound phosphatase has not been known yet. The study assessed the biochemical changes and the alterations in membrane-bound phosphatase activities after the administration of adrenaline in Wistar rats. Adult rats were treated with Adrenaline (Adr) 2 mg/kg body weight and its effect on creatine kinase-MB, lactate dehydrogenase (LDH) and electrolyte levels (Na+, K+, Ionized Ca, Total Ca, Mg2+, PO4) were evaluated. Other parameters investigated include the activities of sodium/potassium adenosine triphosphate (Na+-K+-ATPase), calcium and magnesium dependent adenosine triphosphate (Ca2+ - Mg2+- ATPase).  An impairment in the activities of sodium/potassium adenosine triphosphate (Na+-K+-ATPase), calcium and magnesium dependent adenosine triphosphate (Ca2+ - Mg2+- ATPase) in the vascular tissues of adrenaline treated rats was recorded. Administration of propranolol and Coffee Senna (S. occidentalis) extract was able to reverse the changes in a dose-dependent manner. The result also revealed a significant rise (P?0.05) in the levels of serum creatine kinase-MB and lactate dehydrogenase (LDH) after adrenaline treatment, a significant decrease in serum electrolytes (sodium, calcium, magnesium, phosphate ions), and an insignificant decrease in the levels of potassium ions compared to controls. The changes could be an outcome of the alteration in transmembrane transport mechanisms.