Antidepressant Activity of Methanol Extract of Tapinanthus globiferus (A. Rich) Tiegh in Swiss Mice

Abdullahi Umar*,Magaji M.Garba, ShehuAishatu,Danjuma N. Mohammed
Department of Pharmacology and Therapeutics, Ahmadu Bello University, Nigeria
Corresponding Author: [email protected]; Tel: +2347034615904
Recieved Date: 09 January 2021; Accepted Date: 21 September 2021; Published Date: 04 January
Citation: Umar A, Garba MM, Aishatu S, Mohammed DN. Antidepressant Activity of Methanol Extract of Tapinanthusglobiferus (A. Rich) Tiegh in Swiss Mice.Trop J Nat Prod Res. 2021; 5(12):2123-2126.doi.org/10.26538/tjnpr/v5i12.13 http://www.doi.org/10.26538/tjnpr/v5i12.13
Copyright: © 2021Umaret al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Depression has been a global public health issue for a while and has prompted many researches to develop safer and more effective treatment of depressive illness. It affects how an individual feel, think, relate to others and handle daily activities. The aim of this study is to evaluate the antidepressant activity of the methanol extract of Tapinanthus globiferus in acute model of depression in mice. Phytochemical screening was carried out to identify the different phytochemicals present in the extract. Acute toxic effect of the extract was determined using OECD method. The antidepressant activity of the extract was evaluated using tail suspension test, forced swim tests and confirmed with the open field test.
The methanol extract of T. globiferus contains some phytochemicals some of which have been shown to have antidepressant activity, it was also shown to be practically nontoxic using the OECD guidelines. The extract significantly reduced the immobility time in Tail suspension test but not in the forced swim test. In addition, locomotor activity in open filed test was not significantly affected implying that the extracts activity is not due to locomotor stimulation
The result of the study revealed that the methanol extract of T. globiferus has antidepressant activity.

Keywords: Tapinanthus globiferus, depression, antidepressant, immobility, forced swimming, tail suspension.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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