The Preparation and Characterization of the Solid Dispersion of Piperine with Hydroxypropyl Methylcellulose (HPMC) 2910 Using Spray Drying

Erizal Zaini*, Ridha P. Marhammah, Lili Fitriani, Uswatul Hasanah, Salman Umar
Department of Pharmaceutics, Faculty of Pharmacy, Andalas University, Padang, 25163, Indonesia
Corresponding Author: [email protected]; Tel: +6281395029297
Recieved Date: 16 October 2021; Accepted Date: 07 December 2021; Published Date: 04 January
Citation: Zaini E, Marhammah RP, Fitriani L, Hasanah U, Umar S. The Preparation and Characterization of the Solid Dispersion of Piperine with Hydroxypropyl Methylcellulose (Hpmc) 2910 Using Spray Drying. Trop J Nat Prod Res. 2021; 5(12): 2103-2107 http://www.doi.org/10.26538/tjnpr/v5i12.10
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© 2021 Zaini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Piperine is an alkaloid belonging to the Piperaceae family that has long been used in traditional medicine and has many pharmacological activities. However, piperine does not dissolve easily in aqueous media, resulting in low bioavailability. This study aims to prepare solid dispersions of piperine-HPMC 2910 in order to increase its solubility and dissolution rate. Spray drying was used to prepare solid dispersions in three formulations, with ratios of piperine:HPMC 2910 of 1:1, 1:2, and 2:1 (w/w). The samples were characterized by their solid-state properties using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy, and Scanning Electron Microscope (SEM). Solubility test and dissolution rate were conducted in aqueous medium. The results of the characterization showed a decrease in the intensity of the diffraction peak in the PXRD analysis; a decrease in melting point and a reduction in the endothermic peaks in the DSC analysis; no chemical interactions between piperine and the hydrophilic polymer (HPMC 2910) in the FTIR spectroscopy analysis; and significant changes in crystal morphology in the SEM analysis. The results of the solubility test showed that the highest increment in solubility was in the 1:1 formula, which increased solubility 7.296 times. The highest dissolution rate studies was also shown in the 1:1 formula, where dissolution rate increased 6.284 times. In summary, formation of piperine in solid dispersion with HPMC 2910 by spray drying technique significantly improved the solubility and dissolution rate of piperine.

Keywords: Piperine, HPMC 2910, Solid dispersion, Spray drying, Solubility, Dissolution rate.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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