Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet

Hotimah M. Salim^1*, Lintan F. Kurnia², Tri W. Bintarti³, Handayani Handayani⁴, Michio Shimabukuro⁵

¹Department Medical Biochemistry, Faculty of Medicine, University of Nahdlatul Ulama Surabaya

²Faculty of Medicine, University of Nahdlatul Ulama Surabaya

³Department of Biomolecular Science, Faculty of Medicine, University of Nahdlatul Ulama Surabaya

⁴Department Medical Pharmacology, Faculty of Medicine, Nahdlatul Ulama University of Surabaya

⁵Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, Japan

Corresponding Author: [email protected]; [email protected]; Tel: +62-82233625453

Recieved Date: 28 September 2021; Accepted Date: 30 December 2021; Published Date: 04 January

Citation: Salim HM, Kurnia LF, Bintarti TW, Handayani H, Shimabukuro M. Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet. Trop J Nat Prod Res. 2021; 5(12): 2092-2095 http://www.doi.org/10.26538/tjnpr/v5i12.8

Copyright:

 © 2021 Salim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Dyslipidemia (hyperlipidemia) is a strong risk factor for cardiovascular disease. Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are widely consumed as a traditional Indonesia treatment. The study aimed to investigate the effect of Syzygium polyanthum (Wight) Walp extract in decreasing hypercholesterolemia in Wistar rats. Syzygium polyanthum (Wight) Walp extract (0.72, 0.9 and 1.08 g/day) was administered by gavage to the high fat diet-induced hipercholesterolemia in rats for 2 weeks. The result revealed that the extract administration reduced total cholesterol levels (P<0.05), low-density lipoprotein (LDL) (P<0.05), and triglyceride (TG) (P<0.05) without alteration of body weight. Furthermore, the histological analysis showed that Syzygium polyanthum (Wight) extract decreased lipid accumulation in the liver (p < 0.05). It is concluded that Syzygium polyanthum (Wight) extract significantly lowered total cholesterol and led to lipid accumulation reduction in the liver in hypercholesterolemic Wistar Rat model.