Antibacterial Activity of Rhizophora mucronata Leaves Extract and Its Application in Chewing Gum against Streptococcus mutans and Streptococcus viridans

Hardoko Hardoko1*, Jesika K. Sipayung1, Yuniwaty Halim2
1Fisheries and Product Technology Study Program, Faculty of Fisheries and Marine Sciences, Brawijaya University. Jl. Veteran No. 1 Malang 65113, Indonesia 
2Food Technology Study Program, Faculty of Science and Technology, Universitas Pelita Harapan. Jl. M.H. Thamrin Boulevard, Lippo Karawaci, Tangerang 15811, Indonesia


Corresponding Author: [email protected]; Tel: +62-(0)816160865
Recieved Date: 09 April 2021; Accepted Date: 03 December 2021; Published Date: 04 January
Citation: Hardoko H, Sipayung JK, Halim Y. Antibacterial Activity of Rhizophora mucronata Leaves Extract and Its Application in Chewing Gum against Streptococcus mutans and Streptococcus viridans. Trop J Nat Prod Res. 2021; 5(12): 2068-2073 http://www.doi.org/10.26538/tjnpr/v5i12.4
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© 2021 Hardoko et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Rhizophora mucronata mangrove has antibacterial activity against pathogenic bacterial mostly dental caries-causing bacteria. This research aimed to determine the antibacterial activity of R. mucronata leaves extract and its application in chewing gum against dental caries-causing bacteria, which are Streptococcus mutans and Streptococcus viridans. The method used included inhibitory assay using different concentrations of R. mucronata leaves extract (5.0, 10.0, 15.0, 20.0, 25.0 mg/mL), followed by application of the extract in chewing gum formulation (2, 3, 4, 5 MIC/Minimum Inhibitory Concentration) to inhibit S. mutans and S. viridans. Results showed that R. mucronata leaves extract had strong antibacterial activity at a concentration of 25.0 mg/mL against S. mutans and S. viridans with inhibition zone diameters of 11.35 mm and 23.74 mm, respectively, and MIC of 0.78 and 0.65 mg/mL, respectively. Higher concentrations of R. mucronata extract resulted in higher inhibition, but lower acceptance in chewing gum, because of the astringent taste and dark green colour formed. The most preferred chewing gum was the one formulated with 2 MIC R. mucronata leaves extract with an acceptance level of 3.6 (slightly like) and inhibition zone diameter of 7.02 mm and 8.60 mm against S. mutans and S. viridans, respectively. Thus, chewing gum prepared with R. mucronata extract has the potential to prevent dental caries.

Keywords: Antibacterial, Chewing gum, Dental caries, R. mucronata, Streptococcus.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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