Mercury-Induced Acute Nephrotoxicity in Rats: Treatment with Aqueous Extract of Pistacia atlantica (Desf)

Benahmed Fatiha1,2*, Kharoubi Omar1, Mehrab El azhari2
1Laboratory of Experimental Biotoxicology, Department of Biology, Faculty of Life and Natural Sciences, University of Oran1, Ahmed Ben Bella, 1524 EL M Naouer 31000 Oran, Algeria 
2Department of Biology, Faculty of Sciences and Technology, University of Ahmed Zabana of Relizane , Algeria

Corresponding Author: [email protected]; Tel: +213 (0) 41 51 91 24
Recieved Date: 14 February 2021; Accepted Date: 04 December 2021; Published Date: 04 January
Citation: Fatiha B, Omar K, El azhari M. Mercury-Induced Acute Nephrotoxicity in Rats: Treatment with Aqueous Extract of Pistacia atlantica (Desf). Trop J Nat Prod Res. 2021; 5(12): 2063-2067
 © 2021 Fatiha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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characteristic of mercury toxicity is the generation of free radicals. The purpose of this study is to evaluate the protective effect of the aqueous extract of Pistacia atlantica against mercury-induced oxidative stress in rats. Mercury chloride (HgCl2) was administered intraperitoneally (at 2.5 mg/kg once per week), and P. atlantica was given orally by gavage at a daily dose of 150 mg/kg body weight to rats for 32 days. These results show that HgCl2 caused a significant depletion of the glutathione level and the enzymatic activity of the antioxidant system catalase (CAT), Glutathion peroxidase (GPx,), Glutathion S transferase (GST) at the renal level. These changes were associated with increased lipid peroxidation expressed by a high level of renal Malondialdehyde (MDA) and hydroperoxides (LOOH). However, supplementation with the aqueous extract of Pistacia atlantica modified the toxic effects of mercury by reducing lipid peroxidation. These findings may indicate an antioxidant and protective effect of this plants extract against mercurys harmful effect.

Keywords: Mercury, Liver, Kidney, Redox status, Pistacia atlantica, Rat.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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