Effects of Methanol Leaf Extracts of Selected Plants on the Plasma Electrolytes Levels in Preeclamptic-Induced Wistar Rats

Kenneth Atoe1,2,3* and MacDonald Idu3
1Department of Chemical Pathology, Edo State University Uzairue, Edo State, Nigeria
2Applied Environmental Biosciences and Public Health Research Group, Department of Microbiology, University of Benin, Benin City, Nigeria
3Phytomedicine and Drug Discovery Research Group, Department of Plant Biology and Biotechnology, University of Benin, Benin City, Nigeria

Corresponding Author: [email protected]; Tel: +2348050624628
Recieved Date: 18 July 2021; Accepted Date: 03 October 2021; Published Date: 03 November
Citation: Atoe K and Idu M. Effects of Methanol Leaf Extracts of Selected Plants on the Plasma Electrolytes Levels in Preeclamptic Induced wistar Rats.Trop J Nat Prod Res. 2021; 5(10): 1863-1867. http://www.doi.org/10.26538/tjnpr/v5i10.26
© 2021 Atoe and Idu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Plants have always been used in medicine. Global research on plant medicinal efficacies has led to the development of plant-based medicines. Although their efficacy in the treatment of preeclampsia have not been shown. The study investigated the effects of methanol leaf extracts of Jatropha curcas, Alchornea cordifolia and Secamone afzelii on the plasma electrolytes levels of preeclampticWistar rats. The rats were given Adriamycin (3.5 mg/kg) via a lateral caudal vein after mild ether anesthesia. Female rats were coupled with reproductive male rats for 4 days after 2 weeks. In the vaginal smear, the presence of spermatozoa in the first day of pregnancy was documented. After preeclampsia was observed, the rats were administered extracts (50, 100, and 200 mg/kg body weight) orally on a daily basis during the third trimester and postpartum period. Na, K, and Cl- plasma levels were estimated using an Automatic Electrolyte Analyzer, model BT-500 Plus; whereas Ca and Mg were analyzed by colorimetric method using standard kits. Results showed that in induced preeclampsia, sodium levels were 129.3 mmol/L in the third trimester; however, this level considerably increased to 136.3 – 170.5 mmol/L after administration of various dosages of the extracts. Calcium and magnesium levels were likewise increased (7.1 to 11.9 mg/dL and 1.05 to 2.53 mEq/L, respectively) in induced Wistar rats after extracts administration. The capacity for plant extracts to correct hyponatremia, hypocalcemia and hypomagnesemia during preeclampsia has thus been presented.

Keywords: Preeclampsia, Wistar rats, Methanol leaf extracts, Electrolytes, Pregnancy, Hypertension.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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