Cytotoxic Activity of Two Compounds Extracted from Artocarpus elasticus Reinw. Ex Blume Leaves on Selected Cancer Cell Lines 

Sofa Fajriah*, Megawati Megawati, Akhmad Darmawan
Research Center for Chemistry, National Agency and Research Innovation (BRIN), PUSPIPTEK Gate, Serpong, South Tangerang, Banten 15314, Indonesia
Corresponding Author: [email protected] ; Tel: +62-21-7560929
Recieved Date: 01 February 2021; Accepted Date: 21 October 2021; Published Date: 03 November
Citation: Fajriah S, Megawati M, Darmawan A. Cytotoxic Activity of Two Compounds Extracted from Artocarpus elasticus Reinw. Ex Blume Leaves on Selected Cancer Cell Lines. Trop J Nat Prod Res. 2021; 5(10): 1724-1726. http://www.doi.org/10.26538/tjnpr/v5i10.5
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© 2021 Fajriah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Artocarpus elasticus Reinw. Ex Blume is a genus in the Moraceae family and it contains an abundance of phenolics, such as flavonoids, stilbenoids, dihydrochalcones, dihydrobenzoxanthones, and prenylated flavonoids. This study was aimed at isolating chemical constituents from A. elasticus leaves and investigate the cytotoxic effect of the isolated compounds on selected cancer cell lines. Extract was prepared from A. elasticus leaves, which was followed by fractionation and isolation of chemical constituents via chromatographic technique. The chemical structures of the two compounds obtained from the leaf extract were established using several spectroscopic methods. Cytotoxic effect of both compounds against P388, MCF-7, and T47D cancer cells was investigated using the MTT assay. The results revealed that the two compounds isolated from the leaves of A. elasticus were apigenin and 6-prenyl apigenin. The in vitro cytotoxicity assay showed IC50 values of 14.13, 40.35, and 434.20 ?g/mL and 6.65, 19.75, and 313.61 ?g/mL for apigenin and 6-prenyl apigenin, respectively. This observation demonstrates that 6-prenyl apigenin displayed higher cytotoxic activity compared to apigenin. The finding of this research suggests that both compounds might be useful as anticancer agents.

Keywords: Artocarpus elasticus Reinw. Ex Blume, apigenin, 6-prenyl apigenin, anticancer
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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