Anti-stress Effect of Brown Seaweed Sargassum hystrix J. Agard Ethanol Extract on Cold-Induced Stress in Wistar Rats

Amir Husni1*, Denny N. Fauzi1, Agung E. Nugroho2
1Department of Fisheries, Faculty of Agriculture Universitas Gadjah Mada, Jalan Flora Gedung A4 Bulaksumur Yogyakarta 55281 Indonesia
2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281 Indonesia

Corresponding Author: [email protected]; Tel: 00964 771 392 1237
Recieved Date: 20 April 2021; Accepted Date: 27 September 2021; Published Date: 4 October
Citation: Husni A, Fauzi DN, Nugroho AE. Anti-stress Effect of Brown Seaweed Sargassum hystrix J. Agard Ethanol Extract on Cold-Induced Stress in Wistar Rats. Trop J Nat Prod Res, 2021; 5(9):1547-1550.
© 2021 Husni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Oxidative stress is a potential cause of cell damage, which has deleterious impact on the entire body. Sargassum hystrix contains polyphenols with potential antioxidant properties. Therefore, the objective of this study was to evaluate the effect of the ethanol extract of S. hystrix on the body weight, glucose, total cholesterol, triglyceride and cortisol levels of Wistar rats with cold-induced stress. In this experiment, the rats were orally  administered with 150, 300, and 450 mg/kg of S. hystrix extract (SHE), while the standard anti-stress drug used was diazepam, at a dose of 0.18 mg/kg. The result showed that administration of S. hystrix ethanol extract at various doses was able to lower the glucose, cholesterol and cortisol levels in the Wistar rats. The extract was also shown to cause a reduction in triglyceride levels similar to diazepam at doses of 300 and 450 mg/kg, while the dose of 300 mg/kg was shown to produce the most optimum anti-stress effect in Wistar rats with cold-induced stress.

Keywords: Anti-stress, Ethanol extract, Sargassum hystrix, Marine algae, Cortisol.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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