Effects of Moringa oleifera Seeds on the Serum Electrolytes of Wistar Rats Intoxicated with Aluminum Chloride

Yusufu Dawoye^1*, Grace N. Onwubiko², Henry A. Onwubiko¹

¹Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria Nsukka, Nigeria

²Natural Science Unit, School of General Studies, University of Nigeria Nsukka, Nigeria

Corresponding Author: [email protected]; Tel: +2347085334269; +2347036787613

Recieved Date: 20 December 2020; Accepted Date: 13 May 2021; Published Date: 03 June

Citation: Dawoye Y, Onwubiko GN, Onwubiko HA. Effects of Moringa oleifera Seeds on the Serum Electrolytes of Wistar Rats Intoxicated with Aluminum Chloride. Trop J Nat Prod Res. 2021; 5(5):928-931. http://www.doi.org/10.26538/tjnpr/v5i5.21

Copyright:

© 2021 Dawoye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at  Tropical Journal of Natural Product Research

ABSTRACT

The concentration of serum electrolytes is one of the most commonly used laboratory tests for assessment of a patients clinical conditions and disease states, this is because electrolyte balance is essential for normal functioning of cells and organs of the body. The current study examined the effects of aluminium chloride (AlCl₃) on the serum electrolytes, liver enzymes of 35 wistar rats divided into seven groups of five (n = 5) and treated with 100 and 400 mg/kg body weight of the ethanol and aqueous seed extracts of Moringa oleifera. The study showed the lowering effects of Moringa oleifera on serum electrolytes levels. Further studies showed that alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly (p<0.05) increased from 11.91 ± 0.20 and 11.83 ± 0.40 to 59.23 ± 0.24 and 57.29 ± 0.50 respectively when rats were induced with aluminium chloride toxicity.  Upon treatment with ethanol and aqueous extracts of Moringa oleifera at 100 mg/kg, the levels of ALT and AST significantly (p<0.05) dropped. An increase in the concentrations of the extracts to 400 mg/kg resulted to a significant (P<0.05) elevation of ALT 11.93 ± 0.17 (ethanol) and 11.94 ± 0.07 (aqueous) and AST 11.77 ± 0.25 (ethanol) and 11.78 ± 0.15 (aqueous). The results of this study show that at lower concentrations M. oleifera seeds are effective against AlCl₃ by regulating levels of serum electrolytes, ALT and AST in wistar rats.