Chemical Compositions and Anticancer Activity of Yemeni Plant Flemingia grahamiana Wight & Arn. and Myrtus communis L.

Latifa N. A. Abdulqawi^1,2*, Atheruddin Quadri³, Sehbanul Islam^4,5, Manas K. Santra⁴, Mazahar Farooqui⁶

¹Department of Zoology, Maulana Azad Collage, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad - 431001, Maharashtra, India

²Department of biology, Aden University, Aden, Yemen

³Department of Zoology, Maulana Azad Collage Dr. Rafiq Zakaria Campus, Aurangabad - 431001, Maharashtra, India

⁴National Centre for Cell Science, NCCS Complex, Ganeshkhind Road, Pune, Maharashtra-411007, India     

⁵Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind Road, Pune, Maharashtra- 411007, India 

⁶Department of Chemistry, Maulana Azad Collage Dr. Rafiq Zakaria Campus, Aurangabad - 431001, Maharashtra, India

Corresponding Author: [email protected]; Tel: 00919503081457

Recieved Date: 28 February 2021; Accepted Date: 16 May 2021; Published Date: 03 June

Citation: Abdulqawi LNA, Quadri A, Islam S, Santra MK, Farooqui M. Chemical Compositions and Anticancer Activity of Yemeni Plant Flemingia grahamiana Wight & Arn. and Myrtus communis L. Trop J Nat Prod Res. 2021; 5(5):877-882. http://www.doi.org/10.26538/tjnpr/v5i5.14

Copyright:

 © 2021 Abdulqawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Cancer remains one of the worlds leading causes of death so, there is considerable scientific interest in the continuing discovery of new anticancer products from natural sources. In the present study chemical composition of methanol extracts of F. grahamiana and M. communis was assessed by Gas chromatography-mass spectrometry (GC-MS). In the GC-MS analysis of methanol extracts, 21 phytochemical compounds were identified in F. grahamiana, and 20 compounds in M. communis. The major constituents in F. grahamiana were Cyclohexasiloxane, dodecamethyl- (21.24%), Benzoic acid, 2-(dimethylamino) ethyl ester (11.79%), and Cycloheptasiloxane, tetradecamethyl (11.06%), and in M. communis were Phenol, 3,4-dimethoxy-(24.41%), 3-Buten-2-one, 4-(2,2,6-trimethyl-7-oxabicyclo [4.1.0]hept-1-yl)- (17.44%), and 2-Propanamine,N-(1-methylethyl)-N-nitroso-(8.92%). Further, the anticancer activity of methanol and aqueous extracts of these plants was estimated against MCF-7 cell lines by the MTT method In vitro. Extracts showed a potent anticancer effect in MCF-7 cells. The highest anticancer activity was recorded of aqueous and methanol extracts of M. communis with IC₅₀ 20.49 ± 0.29 and 22.10 ± 0.22 µg/ml, respectively. But extracts F. grahamiana showed moderate anticancer activity and need concentrations of more than 25 µg/ml to inhibit the growth of 50 % of cells. Our study suggests a promising potential for these plants, as anticancer. However, further studies including pharmacological evaluation, and in vivo anticancer activity are required.