@article{To_Tran_Nguyen_Ai Nhung_Nguyen_2023, title={Arginase II Inhibitory Activity of Phenolic Compounds from Caesalpinia sappan L.: http://www.doi.org/10.26538/tjnpr/v7i4.12}, volume={7}, url={https://tjnpr.org/index.php/home/article/view/1873}, abstractNote={<p>Inhibition of arginase from natural compounds has been proposed as a therapeutic approach for the treatment of cardiovascular diseases. Therefore, this study aims to evaluate the arginase inhibitory activity of isolated compounds. Based on bioactivity-guided fractionation, the ethyl acetate fraction was further subjected to column chromatography to obtain seven compounds (<strong>1</strong>−<strong>7</strong>). The chemical structures of the isolated compounds were determined by analyzing NMR spectral data and referring to data from the literature. The arginase II inhibitory activity of compounds <strong>1</strong>–<strong>7 </strong>were investigated <em>in vitro </em>using an enzyme solution prepared from the kidney of anesthetized C57BL/6 mice. Compounds <strong>1</strong>, <strong>2</strong>, and <strong>7 </strong>potentially inhibit arginase II activity, with IC50 values ranging from 8.1 to 14.2 μM, whereas the remaining compounds were inactive. This study is the first to assess compounds isolated from <em>C. sappan </em>heartwood with regard to their arginase inhibitory activity. </p>}, number={4}, journal={Tropical Journal of Natural Product Research (TJNPR)}, author={To, Dao C. and Tran, Manh H. and Nguyen, Phi H. and Ai Nhung, Nguyen T. and Nguyen, Tu T. T.}, year={2023}, month={May}, pages={2744–2748} }