Chemical Constituents from Mallotus pierrei (Gagnep) Airy Shaw S (Euphorbiaceae) and Their Bioactivity Significance

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Published: 2025-07-01
DOI: https://doi.org/10.26538/tjnpr/v9i6.4
Keywords:
Mallolus Pierrei, Euphorbiaceae, antibacterial assay, anti-human immunodeficiency virus assays, cytotoxicity assay

Main Article Content

Rotchana Khaosa-art
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand
Wilart Pompimon
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand
Wipanoot Baison
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand
Yaowares Chusiri
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand
Sukee Sukdee
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand
Weeranuch Karuehanon
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand
Saranya Wattananon
Department of Food Science, Faculty of Agricultural Technology, Lampang Rajabhat University, 52100, Lampang, Thailand
Narong Nuntasaen
Department of Chemistry, Faculty of Science and Center of Innovation in Chemistry, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
Kanoknetr Suksen
Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand
Arthit Chairoungdua
Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand
Jitra Limthongkul
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
Chanita Naparswad
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
Suttiporn Pikulthong
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
Phansuang Udomputtimekakul
Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand

Abstract

The search for new plant-derived biological compounds is a challenging field with diverse applications, including the development of cosmetic products and the creation of medicines for various diseases. This study investigated the phytochemical components, antibacterial effects, and cytotoxic activities of three crude extracts obtained from the mixed leaves and twigs of Mallotus pierrei, a species from the Euphorbiaceae family. Maceration of dried mixed milled leaves and twigs of M. pierrei (2.7 kg) yielded crude extracts: hexane (27.39 g, 1.04 wt%), ethyl acetate (42.05 g, 1.55 wt%), and methanol (162.11 g, 6 wt%). The antibacterial activity tests indicated that the crude hexane extract was active against nine strains of bacteria, exhibiting the same minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ≥3 mg/mL. In contrast, the ethyl acetate and methanol crude extracts exhibited specific activity against three bacterial strains: E. coli (ETEC), E. coli (EPEC), and S. flexneri, with MIC/MBC values of 6.25/>6.25-6.25/80 mg/mL. The cytotoxicity tests indicated that the crude hexane and ethyl acetate extracts had effective dose (ED50) values of 7.72 mg/mL and 8.80 mg/mL when tested on SH-SY5Y cells. However, the activity of the crude ethyl acetate extract was less potent than that of the standard compounds used in this study, such as chloramphenicol and ellipticine. Furthermore, the three crude extracts of M. pierrei were isolated and purified, identifying two significant compounds: friedelin-3 -ol (1) and D-pinitol (2). The findings of this study indicate that M. pierrei has anticancer properties, implying its potential for new medical applications.

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Article Details

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Vol. 9 No. 6 (2025): Tropical Journal of Natural Product Research (TJNPR)

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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biography

Phansuang Udomputtimekakul, Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, 52100, Lampang, Thailand

Tel: +66 816146955

How to Cite

Khaosa-art, R., Pompimon, W., Baison, W., Chusiri, Y., Sukdee, S., Karuehanon, W., Wattananon, S., Nuntasaen, N., Suksen, K., Chairoungdua, A., Limthongkul, J., Naparswad, C., Pikulthong, S., & Udomputtimekakul, P. (2025). Chemical Constituents from Mallotus pierrei (Gagnep) Airy Shaw S (Euphorbiaceae) and Their Bioactivity Significance. Tropical Journal of Natural Product Research (TJNPR), 9(6), 2380-2384. https://doi.org/10.26538/tjnpr/v9i6.4

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