Anti-dermatophytic potentials of Garcinia kola and Vernonia amygdalina extracts
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Abstract
Dermatophytes are cutaneous mycoses that have been linked to a variety of human skin disorders. Herbal drugs developed from plants can be beneficial and would be important for curbing dermatophytosis. This research aimed to ascertain the anti-dermatophytic potentials of Garcinia kola (Gk) and Vernonia amygdalina (Va) and their combinations against selected dermatophytes. In this research, the effect of ethanol extracts of Gk seed and Va leaf and their synergistic interactions were studied on the following dermatophytes: Microsporum audouinii, Trichophyton schoenleinii, and Trichophyton tonsurans. The interaction of the plant extracts revealed that all ratio combinations of the two plants resulted in synergism against M. audouinii and T. tonsurans, while for T. schoenleinii, it occurred only at ratios 5:5, 6:4, 7:3, 8:2, and 9:1 for Gk:Va respectively. The minimum inhibitory concentrations (MICs) of the two plants were also significantly better or equivalent to the MIC of a commercially available dermatophytic drug (50 mg/ml fluconazole) for all the test organisms. In conclusion, dermatophyte infections can be treated using a selected and careful combination of the ethanol extracts of Gk and Va.
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References
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