Male Fertility and Aphrodisiac Potential of African Culinary Spices: Exploring the Evidence
Main Article Content
Abstract
Sexual arousal and fertility are subsets of Male reproductive health which play a significant role in the overall health of males. Food consumed is a source of nutrition crucial to overall health and well-being. This review explores the potential contribution of some African spices to sexual arousal and fertility in males. A search of scientific literature and referred Journals available in electronic databases such as Google Scholar, Pubmed and SciFinder was undertaken. The keywords were aphrodisiac, male fertility and African spices. Spices discussed include Monodora myristica, Allium sativa, Xylopia aethiopica, Tetraplura teteraptera, Piper guinenesis, Zingiber officinale, Aframomum meleguata, and Rhaphiostylis beninensis. Data obtained revealed that the aforementioned African spices are used in ethnomedicine as aphrodisiacs or male fertility enhancers. Some of them possess both properties. Available scientific evidence supported the use of these spices in ethnomedicine. Chemical compounds belonging to different classes of secondary plant metabolites were documented as possibly responsible for the observed activities. This review serves as a useful compilation of information on African spices as potential agents of sexual arousal and fertility in males.
Downloads
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
1. Borget M. Spices plants. In: R. Coste (ed.). The Tropical Agriculturist, Macmillan, London, 1993, p 114.
2. Okwu DE. Evaluation of the Chemical Composition of Indigenous Spices and Flavoring Agents. Global J Pure Appl Sci. 2001; 7: 455-459.
3. Jiang TA, Health Benefits of Culinary Herbs and Spices. J. AOAC Inter. 2019; 102(2): 395 – 411.
4. National Institute of Child Health and Human Development. Men's Reproductive Health. https://www.nichd.nih.gov/health/topics/factsheets/menshealth. Retrieved June 21, 2024
5. De Jonge CJ, Barratt CLR, Aitken RJ, Anderson RA, Baker P, Chan DYL, Connolly MP, Eisenberg ML, Garrido N, Jørgensen N, Kimmins S, Krausz C, McLachlan RI, Niederberger C, O’Bryan MK, Pacey A, Priskorn L, Rautakallio-Hokkanen S, Serour G, Veltman JA, Vogel DL, Vazquez-Levin MH. Current global status of male reproductive health. J. Hum Reprod Open. 2024; 1292):1 – 34. doi 10.1093/hropen/OP hoae017 IS 2.SN 2399-3529.
6. Ferramosca A, Vincenzo Zara. Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Inter J. Mol Sci. 2022; 23(5):1 – 16. doi:10.3390/ijms23052542. Quiroz D, van Andel T. The cultural importance of plants in Western African religions. Econ. Bot. 2018; 72(3):251–262. Doi.org/10.1007/s12231-018-9410-x.
7. Sharma R, Biedenharn KR, Fedor JM, Agarwal A. Lifestyle factors and reproductive health: taking control of your fertility. Reprod. Biol Endocrinol. 2013; 11-66.
8. Sheng Toh YE, Pick Kung LA, Soi Chey M, Rhun K. Overview of the Pharmacological Activity of Aframomum meleguata. Pertanaka J. Trop Agri Sci. 2019; 42(1): 1 – 9.
9. Osuntokun OT. Aframemom melegueta (Grains of Paradise). Annals Microbiol. Infec Diseases. 2020; 3(1): 1 – 6.
10. Kamtchouing P, Mbongue GY, Dimo T, Watcho P, Jatsa HB, Sokeng SD. Effects of Aframomum melegueta and Piper guineense on sexual behaviour of male rats. Behav. Pharmacol. 2002; 13: 243–247.
11. Nguimatio FX, Deeh-Defo PB, Wankeu-Nya M, Ngadjui E, Kamanyi A, Kamtchouing, P, Watcho P. Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations. J. Integrated Med. 2019; 17(5): 359–365. Doi.org/10.1016/j.joim.2019.05.001.
12. Mbongue GY, Kamtchouing P, Dimo T. Effects of the aqueous extract of dry seeds of Aframomum melegueta on some parameters of the reproductive function of mature male rats. Andrologia 2012; 44(1):53–58. Doi.org/10.1111/j.1439-0272.2010.01102.x
13. Allas S, Ngoke V, Hartman NG, Owasa S, Ibea M. Aframomum seeds for improving Penile activity. United States Patent 1999. 5879682.
14. Ayaz E, Alpsoy HC. Garlic (Allium sativum) and traditional medicine. Turk. J. Parasitol. 2007; 31(2):145-149. Turkish. PMID: 17594659.
15. Butt MS, Sultan MT, Butt MS, Iqbal J. Garlic: nature's protection against physiological threats. Crit Rev Food Sci Nutr. 2009; 49(6):538-551.
16. Tudu CK, Dutta T, Ghorai M, Biswas P, Samanta D, Oleksak P, Jha NK, Kumar M, Radha, Proćków J, Pérez de la Lastra JM, Dey A. Traditional uses, phytochemistry, pharmacology and toxicology of garlic (Allium sativum), a storehouse of diverse phytochemicals: A review of research from the last decade focusing on health and nutritional implications. Front. Nutr. 2022; 28:9:949-954. Doi: 10.3389/fnut.2022.929554.
17. Kasuga SN, Uda E, Kyo M, Ushijima N, Morihara Y, Itakura. Pharmacological activities of Aged Garlic Extract in Comparison with Other Garlic Preparations. J. Nutri. 2021;131(3): 1080S-1084S. Doi.org/10.1093/jn/131.3.1080S.
18. Bansel P, Gupta V, Acharya MV, Kaur H, Bansel R, Sharm S. Garlic - Potential substitute to synthetic aphrodisiac. J. Pharm. Res. 2010; 3(12): 3072 – 3074.
19. Ekeanyanwu RC, Ogu GI, Nwachukwu UP. Biochemical characteristics of the African Nutmeg, Monodora myristica. Agric. J. 2010; 5(5): 303–308.
20. Adienbo MA, Perowei A. Sexual function-enhancing potentials of Monodora myristica (African nutmeg) seed extract in experimental animal model. Greener J. Med Sci. 2024; 14(1): 31-36.
21. Okonko LE, Ikpeme EV, Kalu SE. Sperm profile and Testicular Weight Assessment of Albino Rats administered African Nutmeg (Monodora myristica and African Basil (Ocimum gratissimum). Asian J. Biol Sci. 2019; 12:477- 481.
22. Fischer VA1, Effiom-Ekaha OO, Fischer CE1. Morphological and Histological Alterations in the Testes of Wistar Rats Administered Extracts of Monodora myristica Seeds. Egypt Acad. J. Biol Sci. 2020; 12(2): 9- 21.
23. Isawunmi MA. The peppery fruits of Nigeria. Nigerian field. 1984;49(1):37- 44.
24. Iwu MM. Handbook of African medicinal plants. Second Edition, CRC Press, Taylor and Francis Group, Florida, USA; 2014; 45 – 53
25. Alagbe OA, Alagbe GO, Adekunle EA, Ayodele OO, Olorode EM, Oyediran RI, Oloyede EO, Oluwaloni FO, Oyeleye A. Ethnomedicinal Uses and Therapeutic Activities of Piper Guineense: A Review. J. Appl Sci Environ. Manag. 2021; 25(6): 891 – 901.
26. Balogun ME, Besong EE, Djobissie SFA, Mbamalu OS, Obimma JN. A Review of Piper guineense (African Black Pepper). Inter J. Pharm Pharmaceut Res. 2016; 6 (1): 368-384.
27. Kamtchouing P, Mbongue GY, Dimo T, Watcho P, Jatsa HB, Sokeng SD. Effects of Aframomum melegueta and Piper guineense on sexual behaviour of male rats. Behav. Pharmacol. 2002; 13: 243–247.
28. Memudu AE, Akinrinade 1D, Ogundele OM. Dare BJ. Effects of Crude Extract of Dry Fruits of Piper guineense on Male Fertility Parameters of Adult Sprague Dawley Rats”. Eur J Med Plants. 2014; 5(3):297-303. Doi.org/10.9734/EJMP/2015/9466.
29. Ochei JO, Enitan SS, Effedua HI, Omodiale PE, Giwa O. Libido Enhancement Potential of Piper guineense in Male Wistar Rats. Asian J. Biol. 2017; 4(4): 1-9.
30. Mbongue FGY, Kantchouing P, Essame OJL, Yewah PM, Dimo TL. Effect of the aqueous extract of dry fruits of Piper guineense on the reproductive function of adult male rats. Indian J. Pharmacol. 2005; 37(1):30-32.
31. Burkill HM. The useful plants of West Tropical Africa. 4th Edition Macmillan Press. 1999; 1:34-36.
32. Odugbemi T. A Textbook of Medicinal Plants in Nigeria. Tolu Press Lagos, 2008; 3-97.
33. Ofeimun JO, Ayinde BA. Preliminary investigation of the aphrodisiac potential of the methanol extract and fractions of Rhaphiostylis beninensis Planch ex Benth (Icacinaceae) root on male rats. J Sci Pract Pharm. 2017; 4(1):182-188.
34. Aladesanmi AJ. Tetrapleura tetraptera: molluscicidal activity and chemical constituents. Afr. J. Trad Compl and Altern. Med. 2007; 4 (1): 23-32.
35. Uyoh EE, Ita GE, Nwofia. Evaluation of chemical composition of Tetrapleura tetraptera (Schum and Thonn.) taub. From Cross River State, Nigeria. Int. J. Med. Aroma Plants. 2013; 3(3): 386-394.
36. Jimmy EO, Ekpo AJD. Upgrading of lethal dose of Tetrapleura tetraptera extract enhances blood cell values. J. Hematol Thrombo Dis. 2016; 4: 256-257.
37. Tropical Plants Database, Ken Fern. tropical.theferns.info. https://tropical.the ferns.info/view tropical.php? id=Tetrapleura+tetraptera>Accessed 15th June 2024.
38. Adesina SK, Iwalewa EO, Imoh IJ. Tetrapleura tetraptera Taub- Ethnopharmacology, Chemistry, Medicinal and Nutritional Values: A Review. Brit J. Pharmaceut Res. 2016; 12(3): 1-22.
39. Adelakun SA, Ogunlade B, Olawuyi TS, Ojewale AO. Aqueous extract of Tetrapleura tetraptera fruit peels influence copulatory behaviour and maintain testicular integrity in sexually mature male Sprague-Dawley rats: Pro-fertility evaluation and histomorphometry evidence. Curr Res Physiol. 2021; 4: 7-16. Doi.org/10.1016/j.crphys.2021.01.001
40. Otenaike OA, Amao EA Odunsi A. Effect of Tetrapleura tetraptera pulp on testicular and epididymal characteristics of growing rabbit bucks under different feeding regimes. Nig. J. Anim. Prod. 2022; 49(3):93-100. Doi.org/10.51791/njap.v49i3.3539.
41. Okagu IU, Ngwu UE, Odenigbo CJ. Bioactive Constituents of Methanol Extract of Xylopia aethiopica (UDA) Fruits from Nsukka, Enugu State, Nigeria. Open Access. Libra J. 2018; 5(3): 1 -11. Doi.org/10.4236/oalib.1104230.
42. Erhirhie EO, Moke GE. Xylopia Aethiopica: A Review of its Ethnomedicinal, Chemical and Pharmacological Properties. Am. J. Pharm.Tech Res. 2014; 4(6): 22 – 37.
43. Adienbo OM, Nwafor A, Ronami S, Ogbomade RS. Effect of hydro-methanolic extract of Xylopia aethiopica on sexual behaviour in male Wister rats. Inter J. Adv Biol Res. 2013;1(9): 1078 – 1085.
44. Woode E, Alhassan A, Abaidoo CA. Effect of ethanolic fruit extract of Xylopia aethiopica on reproductive function of male rats. Inter. J. Pharm Biomed Res. 2011; 2(3): 161-165.
45. Grzanna R, Lindmark L, Frondoza CG. Ginger--an herbal medicinal product with broad anti-inflammatory actions. J. Med Food. 2005;8(2):125-32. Doi: 10.1089/jmf.2005.8.125.
46. Hosseini J, Mardi MA, Hosseinifar H, Gilani SMA, Dadkhah F, Sepidarkish M. The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double‐blind randomized clinical trial. Inter. J. Repro BioMed 2016; 14(8), 533–540. Doi:10.29252/ijrm.14.8.533.
47. Mares AK, Abid W, Najam WS. The effect of Ginger on semen parameters and serum FSH, LH and testosterone of infertile men. Tikrit Med J. 2012; 18: 322–324.
48. Akhlaghi A, Ahangari YJ, Navidshad B, Pirsaraei ZA, Zhandi M, Deldar H, Rezvani MR, Dadpasand M, Hashemi SR, Poureslami R, Peebles ED. Improvements in semen quality, sperm fatty acids, and reproductive performance in aged Cobb500 breeder roosters fed diets containing dried ginger rhizomes (Zingiber officinale). Poul. Sci, 2014; 93(5):1236–1244.
49. Saeid JM, Shanoon AK, Marbut MM. Effects of Zingiber officinale aqueous extract on semen characteristic and some blood plasma, semen plasma parameters in the broilers breeder male. Inter. J. Poul Sci. 2011; 10(8): 629–633. Doi10.3923/ijps.2011.629.633.
50. Abdelfattah MG, Hussein MT, Ragab SMM, Khalil NSA, Attaai A. The effects of Ginger (Zingiber officinale) roots on the reproductive aspects in male Japanese Quails (Coturnix coturnix japonica). BMC Vet. Res. 2023; 19(34): 1 – 15. Doi.org/10.1186/s12917-023-03576-6.
51. Gholami-Ahangaran M, Karimi-Dehkordi M, Akbari JA, Haj SM, Ostadpoor MA. A systematic review on the effect of Ginger (Zingiber officinale) on the improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans. Vet. Med Sci. 2021; 7(5): 1959–1969. Doi.org/10.1002/vms3.538.
52. Morakinyo AO, Adeniyi OS, Arikawe AP. (2008). Effects of Zingiber Officinale on Reproductive Functions in the Male Rat. Afr J. Biomed Res. 2008;11: 329 – 334.
53. Memudu AE, Akinrinade ID, Ogundele OM, Duru F. Effects of long and short term treatment of aqueous extract of ginger (Zingiber Officinale) on male reproductive function of adult Sprague Dawley rats. J. Med Medic. Sci. 2012; 3(11): 692-696.
Tacouri DD, Ramful-Baboolall D, Puchooa D. In vitro bioactivity and phytochemical screening of selected spices used in Mauritian foods. Asian Pac J. Trop Dis. 2013; 3(4):253–361. doi: 10.1016/S2222-1808(13)60066-3. PMCID: PMC4027315.
54. Akinyemi AJ, Adedara IA, Thome GR, Morsch VM, Rovani MT, Mujica KS, Duarte T, Duarte M, Oboh G, Schetinger MRC. Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats. Toxicol. Reports 2015; 2: 1357-1366, Doi.org/10.1016/j.toxrep.2015.10.001.
55. Shaukat MN, Nazir A, Fallico B. Ginger Bioactives: A Comprehensive Review of Health Benefits and Potential Food Applications. Antioxidants. 2023; 12(11):2015. https://doi.org/10.3390/antiox12112015
56. .Kimura I, Nojima H, Kimura M. Analysis of Chemical-Structure-Activity Relationships to Identify New Pro-Drugs with Unique Mechanisms of Actions in Kampo Medicines and Other Natural Products. Studies Nat. Pdt Chem.1999; 24: 875-932. https://doi.org/10.1016/S1572-5995(00)80057-5.
57. Morihara N, Sumioka I, Moriguchi T, Uda N, Kyo E. Aged garlic extract enhances the production of nitric oxide, Life Sci. 2002; 71: 509–517.
58. Das I, Kan NS, Sooranna SR. Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications, Curr Med Res Opin, 13, 1995, 257–263.
59. Yang J, Wang T, Yang J, Rao K, Zhan Y, Chen B, Liu Z, Li C, Zhuan L, Zang H, Guo M, Xu H, Wang G, Liu H, Ye Q. S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats. Andrology. 2013; 1(3): 487-494. Doi.org/10.1111/j.2047-2927.2012.00060.x.
60. Omoboyowa DA. Bodun DS. Deciphering Phosphodiesterase-5 Inhibitors from Aframemum meleguata: Computational Models against Erectile Dysfunction, in Proceedings of the 9th International Electronic Conference on Medicinal Chemistry. 2023; 1–30.
61. Adefegha SA, Oboh G, Okeke BM, Oyeleye SI. Comparative Effects of Alkaloid Extracts from Aframomum melegueta (Alligator Pepper) and Aframomum danielli (Bastered Melegueta) on Enzymes Relevant to Erectile Dysfunction. J. Diet Suppl. 2017; 14(5): 542-552. Doi: 10.1080/19390211.2016.1272661.