Oral and Acute Dermal Toxicity with Passiflora edulis Sims Aqueous Extract in Sprague-Dawley Rats

Dina K. Sari1*, Liza M. Sari2, Rudy Heryanto3
1Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara, North Sumatera, Indonesia
2Oral Medicine Department, Faculty of Denstistry, Universitas Syah Kuala, Nanggroe Aceh Darussalam, Indonesia
3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia

Corresponding Author: dina@usu.ac.id; Tel: +6281397177693
Recieved Date: August 03, 2020; Accepted Date: October 25, 2020; Published Date: 02 November 2020
Citation: Sari DK, Sari LM, Heryanto R. Oral and Acute Dermal Toxicity with Passiflora edulis Simms Aqueous Extract in Sprague-Dawley Rats. Trop J Nat Prod Res. 2020; 4(10):691-694.  https://doi.org/10.26538/tjnpr/v4i10.6
Copyright: © 2020 Sari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Passiflora edulis (Passion fruit) seeds is rich in phenolic compounds (bioflavonoids) that can inhibit lipid peroxidation and have a strong antioxidant effect.  The present study investigated the acute oral and acute dermal toxicities of the ethanol extract of Passiflora edulis Sims fruit seeds. Acute oral toxicity of P. edulis S. extract was investigated in rats according to the Organisation for Economic Co-operation and Development (OECD) Guideline. The median lethal dose (LD50) was determined to be >15,000 mg/kg body weight. There was a significant increase in body weight (p < 0.05), and no death was recorded during the 14 days of the study. No overt changes were observed in the treated animals compared to controls. Overall, the results showed that oral administration of ethanol extract of P. edulis Sims. did not produce significant toxic effects in rats, indicating that the extract is relatively safe.

Keywords: Acute toxicity, Antioxidant, Fruit seeds, Passiflora edulis, Skin toxicity.
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