Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis

Adeola T. Kola-Mustapha1*, Esther T. Jaiyeola1, Haishat Y. Olufadi-Ahmed2, Hameedat T. Ayotunde1, Yusuf O. Ghazali3

1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin Nigeria
2Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin Nigeria
3FIDSON Healthcare PLC, Lagos, Nigeria

Corresponding Author: kola-mustapha.at@unilorin.edu.ng; atkmusty@yahoo.com; Tel: +234803347548
Recieved Date: September 10, 2020; Accepted Date: October 24, 2020; Published Date: 02 November 2020
Citation: Mustapha AT, Jaiyeola ET, Olufadi-Ahmed HY, Ayotunde HT, Ghazali YO. Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis. Trop J Nat Prod Res. 2020; 4(10):831-837.   https://doi.org/10.26538/tjnpr/v4i10.28
Copyright: © 2020 Mustapha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Oral candidiasis is an opportunistic infection that affects the oral cavity and could worsen the severity of an underlying disease. This research is focused on the formulation of an oral herbal gel from essential oils of Zingiber officinale Rosc. (ZO) and Ocimum basilicum L. (OB) for the potential use in the management of oral candidiasis. Antifungal activities of the oil extracts were evaluated against ten clinical isolates of Candida albicans using the agar well diffusion method and measurement of minimum inhibitory/fungicidal concentration (MIC/MFC). The oils were tested individually and subsequently combined at predetermined ratios. The oils were formulated into carbopol-based gels, the antifungal activity and physico-chemical properties of the gels were assessed. Nystatin was used as a positive control. Sensitivity test showed that Candida albicans isolates were sensitive to each of the essential oil extracts at a concentration of 10%v/v. The essential oil extracts combination of 25:75 (ZO:OB) yielded the highest zones of inhibition which ranged from 28.00 ± 0.65 to 39.00 ± 1.45 mm. The results were higher than that obtained for the nystatin control (26.00 ± 1.20 to 30.00 ± 1.05 mm). Five batches of gels incorporated with the essential oils exhibited good physicochemical characteristics. However, the herbal gels exhibited lower antifungal activity than the essential oils against Candida albicans isolates. These outcomes demonstrate the antifungal activity of the herbal gels and thus its potential for use in the management of oral candidiasis. 

Keywords: Zingiber officinale, Ocimum basilicum, Carbopol gels, Antifungal activity, Dental care, Oral candidiasis.
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