Methanol Extract of Ficus platyphylla Stem Bark Inhibits Cholinesterase Enzyme on Catfish

Ibrahim M. Hassan and Abdullahi I. Ja’afaru

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine Usmanu Danfodiyo University Sokoto.Sokoto State, Nigeria
Corresponding Author: ibrahim.hassan@udusok.edu.ng; Tel: +2349034990736
Recieved Date: September 03, 2020; Accepted Date: November 01, 2020; Published Date: 02 November 2020
Citation: Hassan IM and Ja’afaru AI. Methanol Extract of Ficus platyphylla Stem Bark Inhibit Cholinesterase Enzyme on Catfish. Trop J Nat Prod Res. 2020; 4(10):824-830. https://doi.org/10.26538/tjnpr/v4i10.27
Copyright: © 2020 Hassan and  Ja’afaru. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Traditional medicinal plants have been used for many years by different cultures around the world for the management of different diseases. Current treatments of neurodegenerative diseases are not effective and result in several side effects. Thus, the search for alternative medicines is in high demand. Therefore, this study aim to evaluate the cholinesterase inhibitory effect of Ficus platyphylla 80% methanol (stem bark) extracts. The stem bark was extracted with 80% methanol. A toxicity study was carried out on adult Catfish. Cholinesterase inhibitory activities were also evaluated on the same fishes using Ellman’s method. Result revealed high cholinesterase inhibitory activity of the crude extract with high significant differences at P < 0.001 between the group that was treated with crude extract only, group treated with crude extract, and exposed to arsenic and group that were exposed to arsenic only as well as the group that were maintained in complete media. It can be concluded that the low toxicity and high cholinesterase inhibitory effect of the crude extract could be responsible for its therapeutic effects. Toxicity screening of this crude extract on a mammal such as mice and rat to reaffirm their toxicity and antioxidant screening as well as isolation of bioactive compounds present in this plant part is strongly recommended.

Keywords: Arsenic, Cholinesterase, Extracts, Catfish, Toxicity Study.
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