Effect of Methanol Leaf Extract of Duranta erecta in Rats Induced with Benign Prostatic Hyperplasia

Chioma A. Anosike1, Christopher C. Ugwu1*, Amaechi L. Ogara2, Chiedozie S. Ozioko1, Martins O Ogugofor1
1Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
2Department of Science Lab Technology, University of Nigeria, Nsukka, Enugu State, Nigeria

Corresponding Author: christopher.ugwu.pg02465@unn.edu.ng; Tel: +2347068850676
Recieved Date: August 20, 2020; Accepted Date: October 27, 2020; Published Date: 02 November 2020
Citation: Anosike CA, Ugwu CC, Ogara AL, Ozioko CS, Ogugofor MO. Effect of Methanol Leaf Extract of Duranta erecta in Rats Induced with Benign Prostatic Hyperplasia. Trop J Nat Prod Res. 2020; 4(10):790-795. https://doi.org/10.26538/tjnpr/v4i10.21
Copyright: © 2020 Anosike et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

A common disease among elderly men is benign prostatic hyperplasia (BPH) of which oxidative stress plays important role. The present research evaluates the effect of methanol leaf extract of Duranta erecta (MLEDE) on testosterone-induced BPH in rats. The toxicity level of the extract was examined. Thirty male rats were used for the research, 5 animals served as normal control, 25 animals were induced with BPH using subcutaneous injection of testosterone for four weeks. After induction, they were grouped into five (group 2: BPH untreated, group 3 received ?nasteride: 3mg/kg, group 4-6 received MEDE: 200, 400 and 600 mg/kg). Treatment lasted for three weeks. As the treatment protocol elapsed, all the animals were anesthetised. Blood were obtained via cardiac puncture for the determination of some biochemical parameters. The prostate was weighed, assayed for antioxidant activities and histologically examined. The extract was nontoxic at a dose up to 5000mg/kg. MLEDE (at all doses) and ?nasteride significantly reduced the increases in prostate weight and index, serum testosterone, dihydrotestosterone, PSA and acid phosphatase caused by testosterone induction relative to the BPH rats. Testosterone induction led to increase in MDA and decreases in GSH, SOD, CAT and GPx activities that were significant but were reversed following the administration of MLEDE at all doses. The disruption of prostate histoarchitecture was improved by MLEDE. MLEDE reduced the effect of testosterone-induced BPH conceivably through enhancement of antioxidant defence system. Thus, Duranta erecta could be a promising source of herbal medicine for the management of BPH in men.

Keywords: Antioxidant, Benign Prostatic Hyperplasia (BPH), Duranta erecta, Oxidative stress, Phytotherapy.
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