Anti-Ulcerogenic Effect of Unripe Plantain (Musa paradisiaca) Pulp on Indomethacin-Induced Ulcer in Wistar Rat

Augustine C. Madueke1, Diane O. Ugwu1, Valentine O. Nwanelo1*, Assumpta C. Anosike1, Rapheal C. Anajemba2, Pearl A. Onoh1
1Ethnopharmacology, Food and Drug Delivery Research Group, Department of Biochemistry, Faculty of Biological Sciences, Nsukka University of Nigeria
2Department of Plant Science and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

Corresponding Author: valentine.nwanelo@unn.edu.ng; Tel: +2348036847294
Recieved Date: August 12, 2020; Accepted Date: October 31, 2020; Published Date: 02 November 2020
Citation: Madueke AC, Ugwu DO, Nwanelo VO, Anosike AC, Anajemba RC, Onoh PA. Anti-Ulcerogenic Effect of Unripe Plantain (Musa Paradisiaca) Pulp on Indomethacin-Induced ulcer in Wistar Rat. Trop J Nat Prod Res. 2020; 4(10):784-789. https://doi.org/10.26538/tjnpr/v4i10.20
Copyright: © 2020 Madueke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Musa Paradisiaca has been used in traditional medicine for the treatment of ulcer and our study evaluated the potentials of Musa paradisiaca pulp for the management of ulcer using a standard experimental animal model. The phytochemical, acute toxicity and histological studies of Musa paradisiaca pulp were carried out according to standard methods. The possible anti-ulcer potential investigation was done using 25 rats of 5 rats per group. The animals were administered distilled water 3 mL/kg, extract (100, 200 and 400 mg/kg), cimetidine 100 mg/kg. Ulcer was induced by oral administration of indomethacin (200 mg/kg). No death was recorded in animals that received extract up to 5000 mg/kg body weight.  Our data showed that Musa paradisiaca pulp contains flavonoids, tannins, saponins, glycosides, steroids, alkaloids, resins and reducing sugars. The extract showed a significant reduction (p < 0.05) in mean ulcer index (1.50 ± 0.38, 1.63 ± 0.34 and 1.05 ± 0.29) in animals treated with the extract at all doses relative to untreated control (2.18 ± 0.29). A correlation coefficient of 0.728 existed between percentage inhibition and different concentrations of the extract. The Percentage Ulcer Inhibition of Musa paradisiaca pulp varied with doses. The Percentage Ulcer Inhibition of the extract at 400 mg/kg (51.83%) compared favorably with cimetidine (49.54%). The anti-ulcer studies showed considerable ulcer inhibition (31.19%, 25.23% and 51.83%) by Musa paradisiaca pulp which was confirmed by the results of histological studies. It is concluded that Musa paradisiaca pulp possesses anti-ulcerogenic effects which could be attributed to its phytochemical profile. 

Keywords: Musa paradisiaca, Anti-Ulcerogenic, Indomethacin, Cimetidine, Gastric Ulcer.
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