Hepatocurative Effects of Alpha Lipoic Acid in 5-Fluorouracil-Induced Toxicity Involves Activation of TNF Alpha and NF-?? Signaling Pathway

Jamal-Deen I. Tiiba1*, Mohammed G. Magaji1, Nuhu M. Danjuma1, Abdullahi B. Sallau2
1Pharmacology Department, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Nigeria
2Biochemistry Department, Faculty of Life Sciences, Ahmadu Bello University, Nigeria

Corresponding Author: jamaltiba@yahoo.com; Tel: +2348089243661
Recieved Date: July 18, 2020; Accepted Date: October 30, 2020; Published Date: 02 November 2020
Citation: Tiiba JDI, Magaji MG, Danjuma NM, Sallau AB. Hepatocurative  Effects  of  Alpha  Lipoic  Acid    in  5-Fluorouracil-Induced  Toxicity  involves  Activation    of  TNF  Alpha  and    NF-κβ  signaling  pathway. Trop J Nat Prod Res. 2020; 4(10):765-770.  https://doi.org/10.26538/tjnpr/v4i10.17
Copyright: © 2020 Tiiba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Alpha Lipoic Acid is  an  antioxidant  capable  of  inhibiting  xenobiotic-induced  liver  toxicity  as  reported  in  adriamycin-induced  hepatotoxicity  in  rats.  The  present  research  was  designed  to  study  the  hepatocurative  effects  of  Alpha  Lipoic  acid (ALA)  in  5-fluorouracil (5-FU)-induced  hepatotoxicity  of  Wistar rats.  Intraperitoneal  injection  of  50  mgkg-1  of  5-FU  was  associated  with  significant  (p ? 0.05)  increase  in  the Phenobarbital-induced  sleeping  time,  NF-?B,  TNF-?,  AST, ALP, ALT,  triglyceride, cholesterol and LDL  levels  in  the  toxicity control when compared to the untreated control rats. However,  intraperitoneal  injection  of  50  mgkg-1  of  5-FU  was  associated  with  significant  (p ? 0.05)  decrease in albumin, total protein and HDL levels  in  the  toxicity control when compared to the  negative control rats. Daily oral  post-treatment  with  400  mgkg-1  ALA  after  5-FU  injection  non-significantly  (p ? 0.05)  attenuated  increase  in  the    HDL level  when  compared  to  the  negative    control  group. Intraperitoneal  injection  of  50  mgkg-1  of  5-FU    was  associated  with  remarkable  necrosis when  compared  to the normal  liver  architecture.  Daily  oral  post-treatment  with  400  mgkg-1  ALA    after  5-FU  injection  significantly  (p ? 0.05)  attenuated  these  trends. ALA  has  hepatocurative  potential  in  5-FU-induced  hepatotoxicity  of  Wistar  rats.

Keywords: Alpha Lipoic Acid, 5-Fluorouracil,  Hepatocurative, Nuclear  transcription  factor  kappa  baeta, Tumour  Necrosis  factor  alpha, Wistar  Rats.
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