Antihypertensive Effects of TCT: "Thanh Can Thang", a Vietnamese Tradition Medicine Remedy, in a Cortisone Acetate Rat Model

Quoc B. Pham1, Hong P. Le2, Hong H. Nguyen3, Minh T. Doan1,  Thai H. Pham1, Hoang N. Nguyen4, Manh H. Tran5*, Thanh Ha T. Nguyen4*
1Vietnam University of Traditional Medicine, 2 Tran Phu, Mo Lao, Ha Dong, Hanoi, Vietnam 
2Military Institute of Traditional Medicine, 442 Kim Giang, Đai Kim, Hoang Mai, Ha Noi, Vietnam
3Cardiovascular Center, E Hospital, 87- 89 Tran Cung Street, Cau Giay District, Hanoi, Vietnam
4Vietnam Military Medical University, 160 Phung Hung, Phuc La, Ha Dong, Hanoi, Vietnam 
5Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam ward, Hai Chau district, Da Nang city 550000, Vietnam

Corresponding Author: tmhung801018@gmail.com; hungtm.nckh@donga.edu.vn; nguyentuan000010@gmail.com; Tel: +84-97-214-8084; +84-90-542-8688
Recieved Date: September 07, 2020; Accepted Date: October 31, 2020; Published Date: 02 November 2020
Citation: Pham QB, Le HP, Nguyen HH, Doan MT, Pham TH, Nguyen HN, Tran MH, Nguyen THT. Antihypertensive effects of TCT: "Thanh Can Thang", a Vietnamese Tradition Medicine Remedy, in a Cortisone Acetate Rat Model. Trop J Nat Prod Res. 2020; 4(10):734-738. https://doi.org/10.26538/tjnpr/v4i10.13
Copyright: © 2020 Pham et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

"Thanh Can Thang" (TCT) has been used in Vietnamese traditional medicine to treat clinical hypertension. The remedy contains 10 medicinal herbs, including Ramulus cum Unco Uncariae, Radix Scutellariae, Flos Chrysanthemi indici, Herba Loranthi Gracifilolii, Achyranthes bidentata Blume, Dipsacus japonicas, Alisma orientalis, Ligusticum wallichii, Fossilia Ossis Mastodi, and Zizyphus jujube. This study aimed to investigate the in vivo anti-hypertensive effects of TCT in Wistar rats, using a cortisone acetate model. Hypertension was induced with daily subcutaneous administration of 2.5 mg/kg/day cortisone acetate and 1% sodium chloride in drinking water for 28 days. Two different doses of TCT (14.56 and 43.68 g/kg/day) were used. TCT treatment at both doses resulted in significant decrease in systolic, diastolic, and average blood pressure values. Interestingly, 24 h after the last administration of cortisone acetate, both tested TCT doses were able to restore the levels of systolic, diastolic, and average blood pressure values back to the levels observed in the control group, hence ameliorating hypertension induced by cortisone acetate. This study verifies the usefulness of the traditional medicine TCT in hypertension treatment.

Keywords: Vietnamese traditional medicines, Thanh Can Thang, Anti-hypertension, Cortisone acetate.
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