Aerial Parts of Euphorbia hirta L. in Polar and Non-Polar Solvents: Phytochemical, Antioxidant and Glucose Uptake Studies for Potential Source of Adjunct Drug for Diabetes

Levent B. B. Aquino1#, Marjette Y. U. Barbaza1#, Judson L. T. Ramos1, Mon-Juan Lee2, 3, Shun-Yao Ko4, Chieh-Lun Hsieh5, Kathlia A. De Castro-Cruz1*, Po-Wei Tsai2*
1School of Chemical, Biological, and Materials Engineering, and Sciences, Mapúa University, Intramuros, Manila, 1002 Metro Manila, Philippines
2Department of Medical Sciences Industry, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
3Department of Bioscience Technology, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
4Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
5Ph.D. Educational Management Major in P.E., Graduate School, Emilio Aguinaldo College, Manila, 1007 Metro Manila, Philippines

Corresponding Author: powei@mail.cjcu.edu.tw; kadecastro@mapua.edu.ph ; Tel: +886-6-278-5123; +63-2-8891-0827
Recieved Date: August 19, 2020; Accepted Date: October 30, 2020; Published Date: 02 November 2020
Citation: Aquino LBB, Barbaza MYU, Ramos JLT, Lee MJ, Ko SY, Hsieh CL, De Castro-Cruz KA, Tsai PW. Aerial Parts of Euphorbia hirta L. in Polar and Non-polar Solvents: Phytochemical, Antioxidant and Glucose Uptake Studies for Potential Source of Adjunct Drug for Diabetes. Trop J Nat Prod Res. 2020; 4(10):708-713. https://doi.org/10.26538/tjnpr/v4i10.9
Copyright: © 2020 Aquino et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Euphorbia hirta L. (Euphorbiaceae) is an herbal plant found in countries with tropical and subtropical climates. It contains biologically active components that have pharmacological properties related to progression of oxidative stress and hyperglycemia. In this study, the dried aerial parts of the plant were refluxed using different polar and non-polar solvents such as water, methanol, ethanol, acetone, ethyl acetate, dichloromethane, and hexane. The effect of solvents used during extraction on the number of phytochemicals, antioxidant properties using DPPH and FRAP assays as well as on the glucose uptake were investigated. Results showed that all extracts using various solvents have varied phytochemical contents while polar solvents exhibited higher antioxidant properties both in DPPH and FRAP assays. Likewise, glucose uptake results showed that extracts from water have higher glucose uptake compared to the commercial drug metformin. Thus, components from the water extract of E. hirta L. could be a potential adjunct drug for diabetes.

Keywords: Antidiabetic, Antioxidant, Euphorbia hirta, Flavonoid, Polyphenol.
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