Potency of Fonio Millet to Attenuate Diabetes and Diabetes Related Cardiovascular Diseases

Martin Osibemhe*, Gloria O. Omaji,  Blessing O. Orji, Lawrence E. Ilouno,  Godwin O. Adejo, Timothy T. Geoffery, Joy Okoyomoh,  Ismail N. Muhammad, Philip Iduh

Department of Biochemistry and Molecular Biology, Faculty of  Life Science, Federal University Dutsin-Ma, Katsina State, Nigeria

Corresponding Author: mosibemhe@fudutsinma.edu.ng; Tel: +2348063260886
Recieved Date: August 11, 2020; Accepted Date: September 26, 2020; Published Date: 03 October 2020
Citation: Osibemhe M, Omaji GO, Orji BO, Ilouno LE,  Adejo GO, Geoffery TT, Okoyomoh J,  Muhammad IN, Iduh P. Potency of Fonio Millet to Attenuate Diabetes and Diabetes Related Cardiovascular Diseases. Trop J Nat Prod Res. 2020; 4(9):601-605.  https://doi.org/10.26538/tjnpr/v4i9.18
Copyright: © 2020 Osibemhe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Diabetes has been described as one of the progenitors of cardiovascular diseases. Many researchers have focused their attention on the inherent medicinal potency of herbs in combating diseases with grains highly neglected for their medicinal values. This study is aimed at evaluating the potency of fonio millet (Digitaria exilis) to attenuate diabetes and diabetes related cardiovascular diseases. Twenty-five (25) Wistar rats, selected into five groups of 5 animals per group were used for the study. Streptozotocin (60 mg/kg intraperitoneal injection) was used to induce diabetes. The rats were treated daily with 500 mg/kg aqueous extract of fonio millet, 10% and 20% fonio millet supplemented diets, respectively for a period of 14days. Fasting blood glucose was monitored at intervals of 7days. Malondialdehyde (MDA), some antioxidant enzymes and nitric oxide were assayed in heart homogenate after the 14th day. Streptozotocin (STZ) caused significant (p<0.05) increases in fasting blood glucose from day 1-14 in relation to the basal values. Groups treated with 10% and 20% fonio millet supplemented diet demonstrated significant (p<0.05) fasting blood glucose reduction from day 7-14th. Oral administration of 500 mg/kg aqueous extract did not show any significant change in fasting blood glucose level. The activities of the assayed antioxidant enzymes, MDA and nitric oxide levels were unchanged in all the groups when compared with the control. These findings suggest that 500 mg of aqueous extract of fonio millet did not demonstrate anti-diabetic effect. Whereas 10% and 20% fonio millet supplemented diet demonstrated hypoglycemic and anti-diabetic potential.

Keywords: Attenuate, Diabetes, Fonio millet, Nitric oxide, Streptozotocin.
Back to Articles