Diagnostic Value of Neutrophil-Lymphocyte Ratio in Diagnosis of Asthma: A Case-Control Study in Baghdad

Fatima A. Chaloob1, Qasim S. Al-Mayah2, Thanaa I. Jawed1
1Technical Institute of Al-Dewaniya, Al-Furat Al-Awsat Technical University, Iraq
2Medical Research Unit, College of Medicine, Al-Nahrain University, Iraq

Corresponding Author: dw.ftm@atu.edu.iq; Tel: 00964 7831 8182 262
Recieved Date: July 10, 2020; Accepted Date: September 28, 2020; Published Date: 03 October 2020
Citation: Chaloob FA, Al-Mayah QS, Jawed TI. Diagnostic Value of Neutrophil-Lymphocyte Ratio in Diagnosis of Asthma: A Case-Control Study in Baghdad. Trop J Nat Prod Res. 2020; 4(9):523-526.  https://doi.org/10.26538/tjnpr/v4i9.5
Copyright: © 2020 Chaloob et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Bronchial asthma is a chronic inflammatory illness of the airways accompanied by systemic inflammation in almost all affected patients. This study aimed to evaluate the diagnostic value of neutrophil-lymphocyte ratio (NLR) in the detection of asthma cases in Baghdad, Iraq. It was a case-control study that included a total of 62 adult patients with asthma who were clinically diagnosed by a consultative physician, and 68 age- and gender-matched apparently healthy subjects as a control group. Samples of peripheral blood were collected from each participant. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The receiver operating characteristic (ROC) curve was used to assess the diagnostic value of NLR in the detection of asthma cases. Mean NLR in asthma patients was 2.33 ± 0.89 compared with 1.82 ± 1.04 in controls with a highly significant difference. The area under the curve (AUC) was 0.886 (95% CI = 0.762-0.951), p = 0.002. The sensitivity and specificity of the test at NLR = 2.11 were 82.8% and 73%, respectively. There was a significant positive correlation between NLR and the number of asthma attacks/year (r = 0.247, p = 0.037). Thus, NLR is a reasonable, easy-to-use, and cheap test that can be routinely used to evaluate the inflammatory response in asthmatic patients.

Keywords: Asthma, neutrophil-lymphocyte ratio, receiver operating characteristic curve, inflammation.
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