Phytochemical Characterization and Evaluation of Pharmacological Activities of Leaves of a Mangrove Plant Species - Aegiceras corniculatum (L.)

Shovan L. Debnath1,2, Pritam Kundu1, Mimi Golder1, Biswajit Biswas1,3, Samir K. Sadhu1*
1Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh 
2Department of Pharmacy, Ranada Prasad Shaha University, Narayanganj-1400, Bangladesh
3Department of Pharmacy, Faculty of Biological Science & Technology, Jashore University of Science and Technology, Jashore-7408, Bangladesh

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Recieved Date: July 05, 2020; Accepted Date: September 29, 2020; Published Date: 03 October 2020
Citation: Debnath SL, Kundu P, Golder M, Biswas B, Sadhu SK. Phytochemical Characterization and Evaluation of Pharmacological Activities of Leaves of a Mangrove Plant Species - Aegiceras corniculatum (L.). Trop J Nat Prod Res. 2020; 4(9):516-522.
Copyright: © 2020 Debnath et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Aegiceras corniculatum (L.), a mangrove plant of the Sundarbans, has substantial utilization in the traditional medicinal system of the Indian subcontinent and to justify the plant utility, our study was designed to evaluate its pharmacological potentials. First, the plant’s ability to scavenge different radicals namely 2, 2-diphenyl-1-picryl hydrazyl (DPPH), hydrogen peroxide and superoxide were examined. Quantitative analysis of the antioxidative secondary metabolites such as phenols, flavonoids and tannins were performed. To investigate the antihyperglycemic potential, oral glucose tolerance test (OGTT) was conducted, followed by the ?-glucosidase enzyme inhibitory activity assay. The extract was also evaluated for analgesic, anti-inflammatory and antidiarrhoeal potential in acetic acid-induced writhing test, formaldehyde-induced paw edema test and castor oil-induced antidiarrhoeal assay, respectively. Finally, the cytotoxicity of the plant part was tested through the brine shrimp lethality bioassay. SC50 (concentration required to scavenge 50% radicals) values were found to be 159.7, 151.8 and 346.8 µg/mL, respectively for DPPH, hydrogen peroxide and superoxide radical scavenging assays. The total phenolic, flavonoid and tannin contents were 71 mg GAE/gm, 151 mg QE/gm and 32 mg GAE/gm. Substantial reduction of blood glucose level was observed in OGTT and the concentration required to inhibit 50% of the ?-glucosidase enzyme (IC50) was found to be 10.483 mg/mL. The extract also demonstrated significant analgesic, anti-inflammatory and antidiarrhoeal potential compared to the respective standard drugs. The LC50 of the extract was found to be 10.87 µg/mL in brine shrimp lethality bioassay. All of the results justified the plants utilization in folklore medicinal system.

Keywords: Aegiceras corniculatum, antioxidant, antihyperglycemic, analgesic, antidiarrhoeal.
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