Hepatoprotective Effect of Ethanol Leaf Extract of Ficus thonningii (Blume) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Wistar Rats

Isyaku Abubakar1, Sulaiman S. Kankara2, Umar Lawal2*
1Biotechnology Advanced Research Centre, Sheda Science and Technology Complex, Abuja, Nigeria.
2Department of Biology, Faculty of Natural and Applied Science, Umaru Musa Yar’adua University, Katsina, Nigeria

Corresponding Author: umar.lawal@umyu.edu.ng; Tel: +2348034006631
Recieved Date: June 26, 2020; Accepted Date: August 21, 2020; Published Date: 28 August 2020
Citation: Abubakar I, Kankara SS, Lawal U. Hepatoprotective Effect of Ethanol Leaf Extract of Ficus thonningii (Blume) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Wistar Rats. Trop J Nat Prod Res. 2020; 4(8):406-410.  https://doi.org/10.26538/tjnpr/v4i8.15
Copyright: © 2020 Abubakar et al. Evaluation of the Sweetening Effects of Thaumatococcus d. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Drug-induced liver injury is a potential complication of virtually all medications because the liver has a central role in the metabolism of drugs and toxic substances   The study aimed to evaluate the hepatoprotective activity of the ethanol leaf extract of F. thonningii (Blume) against carbon tetrachloride (CCl4)-induced liver damage in Wistar rats. The hepatoprotective effect was assessed by evaluating the biochemical parameters and histopathological examination of the liver of treated and control animals. The Phytochemical constituents of the extract was further studied using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The results showed that the hepatoprotection of the extract was confirmed by the significant (P < 0.05) decrease in the serum levels of the Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), and Total bilirubin (TB) especially at higher doses. Histopathological examination revealed cytolysis in the liver of untreated animals, while treated animals showed typical standard liver architecture. The GC-MS analysis revealed the presence of palmitic acid, phytol, oleic acid, iconic acid, 9,12-Octadecadienoic acid, and 9-Octadecenal. Findings of this study substantiate the folkloric use of F. thonningii in the management of hepatic ailments.

Keywords: Ficus thonningii (Blume), Carbon tetrachloride (CCl4), Wistar rats, Hepatotoxicity.
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