Coumarins and Carbazole Alkaloid from Clausena excavata Roots and Investigation of their ?-glucosidase Inhibitory Activity

Tin M. Thant1,2, Nanik S. Aminah1*, Alfinda N. Kristanti1, Rico Ramadhan1, Iffa H. Hasna3, Hnin T. Aung4, Yoshiaki Takaya5
1Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, Surabaya, Indonesia
2Department of Chemistry, Mandalar Degree College, Mandalay, Myanmar
3Faculty of Medicine, Kampus A Universitas Airlangga Surabaya, St. Mayjen. Prof. Dr. Moestopo 47, Surabaya 60132, Indonesia 
4Department of Chemistry, Mandalay University, Mandalay, Myanmar
5Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, 468-8503 Japan


Corresponding Author: nanik-s-a@fst.unair.ac.id; Tel: +62-31-5936501
Recieved Date: June 13, 2020; Accepted Date: August 19, 2020; Published Date: 28 August 2020
Citation: Thant TM, Aminah NS, Kristanti AN, Ramadhan R, Hasna IH, Aung HT, Takaya Y. Coumarins and Carbazole Alkaloid from Clausena excavata Roots and Investigation of their α-glucosidase Inhibitory Activity. Trop J Nat Prod Res. 2020; 4(8):334-337.  https://doi.org/10.26538/tjnpr/v4i8.2
Copyright: © 2020 Thant et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Clausena excavata Burm.f. has long been associated with medicinal benefits in folk medicine. This study isolated three known compounds which are two coumarins, umbelliferone (1), clausenidin (2) and one carbazole alkaloid, (2-hydroxy-3-formyl-7-methoxycarbazole (3) from the root of the plant. The compounds were characterized using their 1H-NMR, 13C-NMR, COSY, HSQC and HMBC spectra and confirmed by literature data. The ?-glucosidase inhibitory activity of the extract, fractions, compounds 2 and 3 were evaluated. The methanol extract exhibited higher inhibition against maltase ?-glucosidase with IC50 value 0.020 mg/mL than the n-hexane fraction which IC50 value was 0.041 mg/mL. 

Keywords: Clausena excavata, Umbelliferone, Clausenidin, 2-hydroxy-3-formyl-7-methoxycarbazole, ?-glycosidase, Antidiabetic.
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