Effect of a Phytonutrient-Rich Product and Administration Time on Cyanide-Induced Cardiotoxicity

Omotayo B. Ilesanmi1*, Frances O. Atanu2, Temitope T. Odewale3, Esther Adeogun3, Bruno N. Chikere1, Chinenyenwa U. Alaneme1, David Ogonye1, Joy C. Ogbonna1
1Department of Biochemistry, Faculty of Science, Federal University Otuoke, Yenagoa, Bayelsa State, Nigeria.
2Department of Biochemistry, Faculty of Natural Sciences, Kogi State University, Anyigba, Nigeria.
3Department of Biochemistry, Faculty of Life Sciences, University of Benin, Edo State, Nigeria.

Corresponding Author: ilesanmiob@fuotuoke.edu.ng; Tel: +2348062320794
Recieved Date: June 27, 2019; Accepted Date: July 25, 2020; Published Date: 27 July 2020
Citation: Ilesanmi OB, Atanu OF, Odewale TT, Adeogun E, Nnaemeka CB, Alaneme CU, Ogonye D, Ogbonannya JC. Effect of a Phytonutrient-Rich Product and Administration Time on Cyanide-Induced Cardiotoxicity. Trop J Nat Prod Res. 2020; 4(7):304-309.  https://doi.org/10.26538/tjnpr/v4i7.9
Copyright: © 2020 Ilesanmi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Exposure to cyanide can cause tachycardia, low heartbeat, and cardiac arrest. Trèvo® is a phytochemical-rich product reported to reduce aging and improve immune system. We investigated the ability of trèvo to mitigate the cardiotoxicity of cyanide in male Wistar rats. Twenty-four animals divided into four groups of six animals per group were used for the experiment. Group I (administered distilled water (orally); group II (administered 5 mg/kg bwt KCN [orally]); group III (administered 5 mg/kg bwt KCN [orally] and 2 mL/kg bwt trèvo [orally] after 5 min of exposure to cyanide); group IV (administered 5 mg/kg bwt KCN [orally] + 2 mL/kg bwt trèvo [orally] after 60 min of exposure to cyanide). Malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), cytochrome C oxidase (CCO), as well as p53 were evaluated. KCN caused a significant (P < 0.05) decrease in the activities of CCO, CAT, and SOD, raised the level of p53, AChE, and MDA respectively. Trèvo administered immediately after cyanide exposure suppresses the toxic effect of cyanide to various degrees. Histopathological evaluation shows that KCN did not caused any morphological damage to the heart. It can be summarized that trevo has the potential to reverse the biochemical toxicity of cyanide in the heart. There are still more work to ascertain the level of protection offered by trèvo as an antidote against cyanide poison.

Keywords: KCN, Cardiotoxicity, Natural product, Oxidative stress, p53, Cytochrome C oxidase.
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