Gastro-protective Properties of Acalypha torta Leaf against HCl/Ethanol-Induced Ulceration

Ugochi O. Njoku, Bonaventure Uzowuru, Martins O. Ogugofor
Depertment of Biochemistry, University of Nigeria Nsukka, Enugu State, Nigeria.

Corresponding Author: obinna.ogugofor.pg76810@unn.edu.ng; Tel: +2348105504783
Recieved Date: June 25, 2019; Accepted Date: July 23, 2020; Published Date: 27 July 2020
Citation: Njoku UO, Uzowuru B, Ogugofor MO. Gastro-protective Properties of Acalypha torta Leaf against HCl/Ethanol-Induced Ulceration. Trop J Nat Prod Res. 2020; 4(7):299-303.  https://doi.org/10.26538/tjnpr/v4i7.8
Copyright: © 2020 Njoku et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Acalypha torta is one of the plants used in the treatment of various diseases in traditional medicine. The plant is known to possess antidiarrhoeal, immunomodulatory and antimicrobial activities. Despite the ethnomedicinal uses of this plant, there is a paucity of studies on its gastroprotective activity. However, this study was designed to investigate the gastro-protective properties of Acalypha torta leaf extract. The gastro-protective effect of Acalypha torta leaf methanol extract was evaluated using HCl/ethanol ulcer-induction model. A total of twenty-four (24) animals were randomly grouped into six (6) treatment groups labelled groups 1-6. Groups 1 and 2 received 1% carboxymethyl cellulose (CMC). Group 3 received 30 mg/kg b.w lansoprazole while groups 4-6 received 200, 400 and 600 mg/kg b.w extract, respectively. The present findings revealed that methanol extract of Acalypha torta leaf exerted gastro-protective activity, as shown by its consistent and significant dose-dependent increase in mean ulcer index (MUI) inhibition. Histological investigation of gastric lesions showed that the plant stimulates the scarring cicatrizing process. The gastro protection observed could be attributed to the phytoconstituents of the plant extract which exerted gastro-protective and anti-ulcerogenic effects, possibly by increasing antioxidant enzymes thereby reducing oxidative stress. The gastro-protective properties of the extract could also be due to the ability of the extract to modulate the activities of H+/K+ATPase thereby normalizing the pH of the gastric juice. The extract possesses a dose dependent gastro protective activity.

Keywords: Acalypha torta, Lansoprazole, HCl-ethanol ulcer-induction, Ulcer index, Histology.
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