Antioxidant activities of Daniellia oliveri (Rolfe) Hutch. & Dalziel and Daniellia ogea (Harms) Rolfe ex Holland (Caesalpiniaceae)

Olubusola O. Olaleye1*, Margaret O. Sofidiya1, Joy O. Ogba1, Wale Lasore2
1Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria.
2Department of Biotechnology, Enzyme Technology Division, Federal Institute of Industrial Research, Oshodi, Lagos, Nigeria.

Corresponding Author: olu-olaleye@unilag.edu.ng; Tel: +234-8083225198
Recieved Date: May 20, 2020; Accepted Date: May 29, 2020; Published Date: 31 May 2020
Citation: Olaleye OO, Sofidiya MO, Ogba JO, Lasore W. Antioxidant activities of Daniellia oliveri (Rolfe) Hutch. & Dalziel and Daniellia ogea (Harms) Rolfe ex Holland (Caesalpiniaceae). Trop J Nat Prod Res. 2020; 4(5):210-215.  https://doi.org/10.26538/tjnpr/v4i5.5
Copyright: © 2020 Olaleye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Daniellia oliveri and Daniellia ogea (Caesalpiniaceae) are medicinal plants used for their various ethnomedicinal uses. Cellular damage induced by free radicals has been implicated in several diseases. Antioxidants possess the ability to protect the body from damage caused by free radical-induced oxidative stress through the inhibition of oxidation directly or indirectly. The aim of this study is to evaluate the in-vitro antioxidant activities of the leaves and stem bark extracts of D. oliveri and D. ogea using different in vitro assays including hydroxyl radical scavenging, reducing power, ferrous ion (Fe2+) chelating and lipid peroxidation inhibitory activities. The total polyphenolic contents in the extracts were also determined using standard methods. All the extracts significantly (p < 0.05) inhibited hydroxyl radical in a concentration-dependent manner. The reducing power activity of the extracts were in the order; D. oliveri stem bark > D. ogea stem bark > D. ogea leaf > D. oliveri.  Also, D. oliveri leaf had the highest lipid peroxidation inhibitory activity (IC50 = 3.71 µg/mL) compared with tocopherol and quercetin (IC50 = 4.84 and 26.58 µg/mL). The iron-chelating activity of the extracts was low compared to EDTA. Additionally, total polyphenolic content estimation revealed a considerable amount of phenolics, flavonoids and proanthocyanidins which may be responsible for the antioxidant activity exhibited by the extracts. These results provide the scientific evidence suggesting the potential antioxidant property of D. oliveri and D. ogea extracts in preventing diseases associated with oxidative stress.

Keywords: Daniellia ogea, Daniellia oliveri, Caesalpinioideae, antioxidant, total polyphenolic content.
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