Anti-Epileptic Studies of Chamaecrista mimosoides Ethanol Extract

Asinamai N. Medugu1, James Yakubu2, Victor M. Balami2*, Usiju N. Medugu2, Fave Y. Tata1, Hussaini I. Marte1, Timothy, S. Yerima1
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria.
2Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Borno State, Nigeria.

Corresponding Author: bmusavictor@yahoo.com; Tel: +2348066322932
Recieved Date: May 06, 2020; Accepted Date: May 28, 2020; Published Date: 31 May 2020
Citation: Medugu AN, Yakubu J, Balami VM, Medugu UN, Tata FY, Marte HI, Yerima TS. Anti-Epileptic Studies of Chamaecrista mimosoides Ethanol Extract. Trop J Nat Prod Res. 2020; 4(5):203-209.  https://doi.org/10.26538/tjnpr/v4i5.4
Copyright: © 2020 Medugu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Plant has been man’s most formidable friend for survival, both as food and medicine since time immemorial. This research work aimed to establish a scientific basis for the use of Chamaecrista mimosoides in traditional medicine as anti-epileptic medication. The study was carried out in two (2) phases. Phase I (Chemical Analysis): The whole plant part of Chamaecrista mimosoides was extracted with ethanol and screened for phytochemicals. Phase II (Pharmacological studies): Acute toxicity study was carried out using Lorke’s method and the antiepileptic activity was evaluated using maximal electroshock-induced seizure test in day-old chicks, pentylenetetrazole (PTZ)- and strychnine-induced seizure in mice. The phytochemical study revealed the presence of saponins, cardiac glycosides, tannins, flavonoids, terpenoids and cardenolides. The intraperitoneal median lethal dose value (LD50) of Chamaecrista mimosoides  ethanol extract encoded CME in mice was greater than 5000 mg/kg, indicating the extract is relatively safe. The extract at the experimental doses of 250 and 500 mg/kg body weight protected 100% each, of animals against PTZ-induced convulsion; protected 60% and 80% of mice against death induced by strychnine; but had 0% protection of chicks against Tonic Hindlimb Extension (THLE) phase of the Maximal Electroshock Test (MEST) at p < 0.05.

Keywords: Chamaecrista mimosoides, Phytochemical, Antiepileptic, Pentylenetetrazole (PTZ), Maximal electroshock¸strychnine.
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